K
Kenjiro Yoshikawa
Publications - 16
Citations - 676
Kenjiro Yoshikawa is an academic researcher. The author has contributed to research in topics: DNA methylation & Sessile serrated adenoma. The author has an hindex of 10, co-authored 16 publications receiving 618 citations.
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Journal ArticleDOI
Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect.
Hiromu Suzuki,Eiichiro Yamamoto,Masanori Nojima,Masahiro Kai,Hiro-o Yamano,Kenjiro Yoshikawa,Tomoaki Kimura,Toyoki Kudo,Eiji Harada,Tamotsu Sugai,Hiroyuki Takamaru,Takeshi Niinuma,Reo Maruyama,Hiroyuki Yamamoto,Takashi Tokino,Kohzoh Imai,Minoru Toyota,Yasuhisa Shinomura +17 more
TL;DR: The results suggest that miR-34b and miC-34c are novel tumor suppressors frequently silenced by DNA methylation in GC, that methylation of miR -34b/c is involved in an epigenetic field defect and that the methylation might be a predictive marker of GC risk.
Journal ArticleDOI
A Novel Pit Pattern Identifies the Precursor of Colorectal Cancer Derived From Sessile Serrated Adenoma
Tomoaki Kimura,Eiichiro Yamamoto,Hiro-o Yamano,Hiromu Suzuki,Seiko Kamimae,Masanori Nojima,Takeshi Sawada,Masami Ashida,Kenjiro Yoshikawa,Ryo Takagi,Ryusuke Kato,Taku Harada,Ryo Suzuki,Reo Maruyama,Masahiro Kai,Kohzoh Imai,Yasuhisa Shinomura,Tamotsu Sugai,Minoru Toyota +18 more
TL;DR: The results suggest the Type II-O pit pattern is a useful hallmark of the premalignant stage of CRCs with MSI and CIMP, which could serve to improve the efficacy of colonoscopic surveillance.
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Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype.
Eiichiro Yamamoto,Hiromu Suzuki,Hiro-o Yamano,Reo Maruyama,Masanori Nojima,Seiko Kamimae,Takeshi Sawada,Masami Ashida,Kenjiro Yoshikawa,Tomoaki Kimura,Ryo Takagi,Taku Harada,Ryo Suzuki,Akiko Sato,Masahiro Kai,Yasushi Sasaki,Takashi Tokino,Tamotsu Sugai,Kohzoh Imai,Yasuhisa Shinomura,Minoru Toyota +20 more
TL;DR: Analysis of mixed lesions containing both precancerous and malignant components revealed that most aberrant methylation is acquired at the precursor stage, whereas copy number aberrations are acquired during the progression from precursor to malignant lesion.
Journal ArticleDOI
Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk
Ryo Suzuki,Eiichiro Yamamoto,Masanori Nojima,Reo Maruyama,Hiro-o Yamano,Kenjiro Yoshikawa,Tomoaki Kimura,Taku Harada,Masami Ashida,Takeshi Niinuma,Akiko Sato,Katsuhiko Nosho,Hiroyuki Yamamoto,Masahiro Kai,Tamotsu Sugai,Kohzoh Imai,Hiromu Suzuki,Yasuhisa Shinomura +17 more
TL;DR: The results suggest that methylation of miR-34b/c in the mucosa of the noncancerous gastric body may be a useful biomarker for predicting the risk of metachronous GC.
Journal ArticleDOI
Epigenetic Alteration of DNA in Mucosal Wash Fluid Predicts Invasiveness of Colorectal Tumors
Seiko Kamimae,Eiichiro Yamamoto,Hiro-o Yamano,Masanori Nojima,Hiromu Suzuki,Masami Ashida,Tomo Hatahira,Akiko Sato,Tomoaki Kimura,Kenjiro Yoshikawa,Taku Harada,Seiko Hayashi,Hiroyuki Takamaru,Reo Maruyama,Masahiro Kai,Morie Nishiwaki,Tamotsu Sugai,Yasushi Sasaki,Takashi Tokino,Yasuhisa Shinomura,Kohzoh Imai,Minoru Toyota +21 more
TL;DR: Analysis of the methylation of DNA in mucosal wash fluid may be a good molecular marker for predicting the invasiveness of colorectal tumors.