T
Tomoaki Kimura
Publications - 11
Citations - 751
Tomoaki Kimura is an academic researcher. The author has contributed to research in topics: DNA methylation & Cancer. The author has an hindex of 10, co-authored 11 publications receiving 702 citations.
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Journal ArticleDOI
Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect.
Hiromu Suzuki,Eiichiro Yamamoto,Masanori Nojima,Masahiro Kai,Hiro-o Yamano,Kenjiro Yoshikawa,Tomoaki Kimura,Toyoki Kudo,Eiji Harada,Tamotsu Sugai,Hiroyuki Takamaru,Takeshi Niinuma,Reo Maruyama,Hiroyuki Yamamoto,Takashi Tokino,Kohzoh Imai,Minoru Toyota,Yasuhisa Shinomura +17 more
TL;DR: The results suggest that miR-34b and miC-34c are novel tumor suppressors frequently silenced by DNA methylation in GC, that methylation of miR -34b/c is involved in an epigenetic field defect and that the methylation might be a predictive marker of GC risk.
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A Novel Pit Pattern Identifies the Precursor of Colorectal Cancer Derived From Sessile Serrated Adenoma
Tomoaki Kimura,Eiichiro Yamamoto,Hiro-o Yamano,Hiromu Suzuki,Seiko Kamimae,Masanori Nojima,Takeshi Sawada,Masami Ashida,Kenjiro Yoshikawa,Ryo Takagi,Ryusuke Kato,Taku Harada,Ryo Suzuki,Reo Maruyama,Masahiro Kai,Kohzoh Imai,Yasuhisa Shinomura,Tamotsu Sugai,Minoru Toyota +18 more
TL;DR: The results suggest the Type II-O pit pattern is a useful hallmark of the premalignant stage of CRCs with MSI and CIMP, which could serve to improve the efficacy of colonoscopic surveillance.
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Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype.
Eiichiro Yamamoto,Hiromu Suzuki,Hiro-o Yamano,Reo Maruyama,Masanori Nojima,Seiko Kamimae,Takeshi Sawada,Masami Ashida,Kenjiro Yoshikawa,Tomoaki Kimura,Ryo Takagi,Taku Harada,Ryo Suzuki,Akiko Sato,Masahiro Kai,Yasushi Sasaki,Takashi Tokino,Tamotsu Sugai,Kohzoh Imai,Yasuhisa Shinomura,Minoru Toyota +20 more
TL;DR: Analysis of mixed lesions containing both precancerous and malignant components revealed that most aberrant methylation is acquired at the precursor stage, whereas copy number aberrations are acquired during the progression from precursor to malignant lesion.
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Carbon dioxide insufflation for colonoscopy: evaluation of gas volume, abdominal pain, examination time and transcutaneous partial CO2 pressure.
Hiro-o Yamano,Kenjirou Yoshikawa,Tomoaki Kimura,Eiichirou Yamamoto,Eiji Harada,Toyoki Kudou,Ryusuke Katou,Yasuko Hayashi,Kentarou Satou +8 more
TL;DR: The CO2 gas volume used in this study was much greater than that reported by others, but the pCO2 values were still within the normal reference range, indicating the safety of CO2 insufflation over a greater range of CO1 gas volume.
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Evaluation of magnifying colonoscopy in the diagnosis of serrated polyps.
Shinya Ishigooka,Masahito Nomoto,Nobuyuki Obinata,Yoshichika Oishi,Yoshinori Sato,Satoko Nakatsu,Midori Suzuki,Yoshiko Ikeda,Tadateru Maehata,Tomoaki Kimura,Yoshiyuki Watanabe,T. Nakajima,Hiro O. Yamano,Hiroshi Yasuda,Fumio Itoh +14 more
TL;DR: This study examined 118 lesions excised in the authors' hospital as suspected serrated lesions after magnified observation between January 2008 and September 2011, finding that SSA/Ps were characterized as larger in diameter than TSAs and HPs and cancer was present in three lesions, in all of which a type VI pit pattern was also present within the same lesion.