K
Kenneth A. Stauderman
Researcher at University of Cambridge
Publications - 59
Citations - 6953
Kenneth A. Stauderman is an academic researcher from University of Cambridge. The author has contributed to research in topics: Voltage-dependent calcium channel & Calcium. The author has an hindex of 24, co-authored 55 publications receiving 6537 citations. Previous affiliations of Kenneth A. Stauderman include Torrey Pines Institute for Molecular Studies.
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Journal ArticleDOI
STIM1, an essential and conserved component of store-operated Ca2+ channel function
Jack Roos,Paul J. Digregorio,Andriy V. Yeromin,Kari Lynn Ohlsen,Maria I. Lioudyno,Shenyuan L. Zhang,Olga Safrina,J. Ashot Kozak,Steven L. Wagner,Michael D. Cahalan,Gonul Velicelebi,Kenneth A. Stauderman +11 more
TL;DR: It is proposed that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels.
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STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
Shenyuan L. Zhang,Ying Yu,Jack Roos,J. Ashot Kozak,Thomas J. Deerinck,Mark H. Ellisman,Kenneth A. Stauderman,Michael D. Cahalan +7 more
TL;DR: It is proposed that STIM1 functions as the missing link between Ca2+ store depletion and SOC influx, serving as aCa2+ sensor that translocates upon store depletion to the plasma membrane to activate CRAC channels.
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Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.
Shenyuan L. Zhang,Andriy V. Yeromin,Xiang Zhang,Ying Yu,Olga Safrina,Aubin Penna,Jack Roos,Kenneth A. Stauderman,Michael D. Cahalan +8 more
TL;DR: Using an unbiased genome-wide RNA interference screen in Drosophila S2 cells, 75 hits are identified that strongly inhibited Ca(2+) influx upon store emptying by thapsigargin, including Stim and olf186-F, a member of a highly conserved family of four-transmembrane spanning proteins with homologs from Caenorhabditis elegans to human.
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Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats.
Z. David Luo,Sandra R. Chaplan,Emiliano S. Higuera,Linda S. Sorkin,Kenneth A. Stauderman,Mark E. Williams,Tony L. Yaksh +6 more
TL;DR: Using a rat neuropathic pain model in which gabapentin-sensitive tactile allodynia develops after tight ligation of the left fifth and sixth lumbar spinal nerves, a >17-fold, time-dependent increase in α2δ subunit expression in DRGs ipsilateral to the nerve injury is found, suggesting that DRG α2 δ regulation may play an unique role in neuroplasticity after peripheral nerve injury.
Journal ArticleDOI
Functional Consequences of Mutations in the Human α1A Calcium Channel Subunit Linked to Familial Hemiplegic Migraine
Michael Hans,Siro Luvisetto,Mark E. Williams,Michele Spagnolo,Arturo Urrutia,Angelita Tottene,Paul Brust,Edwin C. Johnson,Michael M. Harpold,Kenneth A. Stauderman,Daniela Pietrobon +10 more
TL;DR: The data show that the FHM mutations can lead to both gain- and loss-of-function of human P/Q-type calcium channels.