Kenneth A. Stauderman

TL;DR: The results indicate that stably expressed α3β2 and α4β2 human nAChRs are pharmacologically and functionally distinct.

TL;DR: Im intravenous administration of CM4620 reduces the severity of acute pancreatitis in the rat, a hitherto untested species, and it is shown that SOCE via STIM1/Orai complexes promotes activation and fibroinflammatory gene expression within pancreatic stellate cells.

TL;DR: It is concluded that group I mGluRs can modulate neuronal Ca2+ channels using a variety of signal transduction pathways and proposed that the relative contributions of different pathways may exemplify the diversity of responses mediated by these receptors in the CNS.

TL;DR: The challenges associated with drug discovery and development on CRAC channels and the approaches employed to date are discussed, as well as the results, starting from initial high-throughput screens for CRAC channel modulators and progressing through target selection and justification, descriptions of pharmacological, safety and toxicological profiles of compounds, and finally the entry ofCRAC channel inhibitors into clinical trials.

TL;DR: In this paper, compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels, are described and methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.