K
Kenneth E. White
Researcher at Indiana University
Publications - 123
Citations - 12720
Kenneth E. White is an academic researcher from Indiana University. The author has contributed to research in topics: Fibroblast growth factor 23 & Hypophosphatemia. The author has an hindex of 46, co-authored 116 publications receiving 11697 citations. Previous affiliations of Kenneth E. White include University of Adelaide & Indiana University – Purdue University Indianapolis.
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Journal ArticleDOI
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
Kenneth E. White,Wayne E. Evans,Jeffery L.H. O'Riordan,Marcy C. Speer,Michael J. Econs,Bettina Lorenz-Depiereux,Bettina Lorenz-Depiereux,Monika Grabowski,Monika Grabowski,Thomas Meitinger,Thomas Meitinger,Tim M. Strom +11 more
TL;DR: A positional cloning approach was used to identify the ADHR gene which included the annotation of 37 genes within 4 Mb of genomic sequence, and missense mutations in a gene encoding a new member of the fibroblast growth factor (FGF) family, FGF23 were identified.
Journal ArticleDOI
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
Jian Q. Feng,Leanne M Ward,Shiguang Liu,Yongbo Lu,Yixia Xie,Baozhi Yuan,Xijie Yu,Frank Rauch,Siobhan I. Davis,Shubin Zhang,Hector F. Rios,Marc K. Drezner,L. Darryl Quarles,Lynda F. Bonewald,Kenneth E. White +14 more
TL;DR: Mechanistic studies using Dmp1-null mice demonstrated that absence of DMP1 results in defective osteocyte maturation and increased FGF23 expression, leading to pathological changes in bone mineralization, suggesting a bone-renal axis that is central to guiding proper mineral metabolism.
Journal ArticleDOI
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia.
Kenneth B. Jonsson,Richard J. Zahradnik,Tobias E. Larsson,Kenneth E. White,Toshitsugu Sugimoto,Yasuo Imanishi,Takehisa Yamamoto,Geeta Hampson,Hiroyuki Koshiyama,Östen Ljunggren,Koichi Oba,In Myung Yang,Akimitsu Miyauchi,Michael J. Econs,Jeffrey R. Lavigne,Harald Jüppner,Harald Jüppner +16 more
TL;DR: FGF-23 is readily detectable in the plasma or serum of healthy persons and can be markedly elevated in those with oncogenic osteomalacia or X-linked hypophosphatemia, suggesting that this growth factor has a role in phosphate homeostasis.
Journal ArticleDOI
FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting
Mara Riminucci,Michael T. Collins,Neal S. Fedarko,Natasha Cherman,Alessandro Corsi,Alessandro Corsi,Kenneth E. White,Steven G. Waguespack,Anurag Gupta,Tamara S. Hannon,Michael J. Econs,Paolo Bianco,Paolo Bianco,Pamela Gehron Robey +13 more
TL;DR: It is found that FGF-23 is produced by normal and FD osteoprogenitors and bone-forming cells in vivo and in vitro and may play an important role in the renal phosphate-wasting syndrome associated with FD/MAS.
Journal ArticleDOI
Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature.
Andrew L. Folpe,Julie C. Fanburg-Smith,Steven D. Billings,Michele Bisceglia,Franco Bertoni,Justin Cho,Michael J. Econs,Carrie Y. Inwards,Suzanne M. Jan de Beur,Thomas Mentzel,Elizabeth A. Montgomery,Michal Michal,Markku Miettinen,Stacey E. Mills,John D. Reith,John X. O'Connell,Andrew E. Rosenberg,Brian P. Rubin,Donald E. Sweet,Tuyethoa N. Vinh,Lester E. Wold,B. Wehrli,Kenneth E. White,Richard J. Zaino,Sharon W. Weiss +24 more
TL;DR: Most cases of mesenchymal tumor-associated OO, both in the present series and in the reported literature, are due to PMTMCT, and improved recognition of their histologic spectrum, including the presence of bone or osteoid-like matrix in otherwise typical cases and the existence of malignant forms, should allow distinction from other meschymal tumors.