Kerong Deng

TL;DR: A novel near-infrared (NIR) light activated photosensitizer for PDT based on TiO2-coated upconversion nanoparticle (UCNP) core/shell nanocomposites (UCNPs@TiO2 NCs) is designed and could serve as an effective photosensitizeder for NIR light mediated PDT in antitumor therapy.

TL;DR: Hollow‐structured CuS@Cu2S@Au nanoshell/satellite nanoparticles are designed and synthesized for enhanced photothermal therapy and photoswitchable targeting theranostics and stimuli‐responsive targeted cancer therapy.

TL;DR: To address current obstacles of PDT treatment and facilitate the effective utilization, several innovative strategies are developed and introduced into PDT nanosystems, including the conjugation with targeted moieties, O2 self-sufficient PDT, dual photosensitizers-loaded PDT nanoplatform, and PDT-involved synergistic therapy.

TL;DR: Through the in vitro and in-vivo experiment results, the dual-photosensitizers nanoplatform presents enhanced anti-tumor efficacy by effective targeting cellular uptake and taking full advantage of upconversion emission, which may make a major step toward next generation of NIR-mediated PDT.

TL;DR: This work develops a novel aptamer-guided nanocarrier based on the mesoporous metal-organic framework (MOF) shell and up-conversion luminescent NaYF4:Yb3+/Er3+ nanoparticles (UCNPs) core for the first time to achieve goals of simultaneous targeted labeling and therapy of cancer cells.