K
Kexian Zhu
Researcher at Harvard University
Publications - 10
Citations - 4934
Kexian Zhu is an academic researcher from Harvard University. The author has contributed to research in topics: Induced pluripotent stem cell & Cellular differentiation. The author has an hindex of 8, co-authored 10 publications receiving 4072 citations. Previous affiliations of Kexian Zhu include University of Wisconsin-Madison.
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Journal ArticleDOI
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
Xiaojun Lian,Cheston Hsiao,Gisela F. Wilson,Kexian Zhu,Laurie B. Hazeltine,Samira M. Azarin,Kunil K. Raval,Kunil K. Raval,Jianhua Zhang,Jianhua Zhang,Timothy J. Kamp,Timothy J. Kamp,Sean P. Palecek +12 more
TL;DR: It is shown that temporal modulation of Wnt signaling is both essential and sufficient for efficient cardiac induction in hPSCs under defined, growth factor-free conditions.
Journal ArticleDOI
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
Xiaojun Lian,Jianhua Zhang,Samira M. Azarin,Kexian Zhu,Laurie B. Hazeltine,Xiaoping Bao,Cheston Hsiao,Timothy J. Kamp,Sean P. Palecek +8 more
TL;DR: Functional human cardiomyocytes differentiated via these protocols may constitute a potential cell source for heart disease modeling, drug screening and cell-based therapeutic applications.
Journal ArticleDOI
In vivo gene editing in dystrophic mouse muscle and muscle stem cells
Mohammadsharif Tabebordbar,Kexian Zhu,Jason Cheng,Wei Leong Chew,Jeffrey J. Widrick,Winston X. Yan,Winston X. Yan,Claire Maesner,Elizabeth Y Wu,Ru Xiao,F. Ann Ran,F. Ann Ran,Le Cong,Le Cong,Feng Zhang,Feng Zhang,Luk H. Vandenberghe,George M. Church,Amy J. Wagers +18 more
TL;DR: In this paper, the authors developed and tested a direct gene-editing approach to induce exon deletion and recover dystrophin expression in the mdx mouse model of Duchenne muscular dystrophy.
In vivo gene editing in dystrophic mouse muscle and muscle stem cells
Mohammadsharif Tabebordbar,Kexian Zhu,Jason Cheng,Wei Leong Chew,Jeffrey J. Widrick,Claire Maesner,Elizabeth Y Wu,Ru Xiao,Fei Ran,Luk H. Vandenberghe,George M. Church,Amy J. Wagers,Winston X. Yan,Le Cong,Feng Zhang +14 more
TL;DR: A direct gene-editing approach is developed and tested to induce exon deletion and recover dystrophin expression in the mdx mouse model of DMD and partially recovered muscle functional deficiencies and generated a pool of endogenously corrected myogenic precursors in m dx mouse muscle.
Journal ArticleDOI
A multifunctional AAV-CRISPR-Cas9 and its host response
Wei Leong Chew,Mohammadsharif Tabebordbar,Jason Cheng,Prashant Mali,Elizabeth Y Wu,Alex Hay-Man Ng,Kexian Zhu,Amy J. Wagers,George M. Church,George M. Church +9 more
TL;DR: The results reveal that AAV–CRISPR–Cas9 evokes host responses with distinct cellular and molecular signatures, but unlike alternative delivery methods, does not induce extensive cellular damage in vivo.