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Wei Leong Chew
Researcher at Agency for Science, Technology and Research
Publications - 28
Citations - 2753
Wei Leong Chew is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Genome editing & Immune system. The author has an hindex of 11, co-authored 25 publications receiving 2175 citations. Previous affiliations of Wei Leong Chew include Genome Institute of Singapore & Harvard University.
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Journal ArticleDOI
In vivo gene editing in dystrophic mouse muscle and muscle stem cells
Mohammadsharif Tabebordbar,Kexian Zhu,Jason Cheng,Wei Leong Chew,Jeffrey J. Widrick,Winston X. Yan,Winston X. Yan,Claire Maesner,Elizabeth Y Wu,Ru Xiao,F. Ann Ran,F. Ann Ran,Le Cong,Le Cong,Feng Zhang,Feng Zhang,Luk H. Vandenberghe,George M. Church,Amy J. Wagers +18 more
TL;DR: In this paper, the authors developed and tested a direct gene-editing approach to induce exon deletion and recover dystrophin expression in the mdx mouse model of Duchenne muscular dystrophy.
In vivo gene editing in dystrophic mouse muscle and muscle stem cells
Mohammadsharif Tabebordbar,Kexian Zhu,Jason Cheng,Wei Leong Chew,Jeffrey J. Widrick,Claire Maesner,Elizabeth Y Wu,Ru Xiao,Fei Ran,Luk H. Vandenberghe,George M. Church,Amy J. Wagers,Winston X. Yan,Le Cong,Feng Zhang +14 more
TL;DR: A direct gene-editing approach is developed and tested to induce exon deletion and recover dystrophin expression in the mdx mouse model of DMD and partially recovered muscle functional deficiencies and generated a pool of endogenously corrected myogenic precursors in m dx mouse muscle.
Journal ArticleDOI
A multifunctional AAV-CRISPR-Cas9 and its host response
Wei Leong Chew,Mohammadsharif Tabebordbar,Jason Cheng,Prashant Mali,Elizabeth Y Wu,Alex Hay-Man Ng,Kexian Zhu,Amy J. Wagers,George M. Church,George M. Church +9 more
TL;DR: The results reveal that AAV–CRISPR–Cas9 evokes host responses with distinct cellular and molecular signatures, but unlike alternative delivery methods, does not induce extensive cellular damage in vivo.
Journal ArticleDOI
TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.
Jinju Li,Patrick Kanju,Michael Patterson,Wei Leong Chew,Seung-Hyun Cho,Ian Gilmour,Tim Oliver,Ryohei Yasuda,Andrew J. Ghio,Sidney A. Simon,Wolfgang Liedtke +10 more
TL;DR: The novel concept of air pollution–responsive ciliary signal transduction from PAR-2 to TRPV4 in human respiratory epithelia will accelerate rationally targeted therapies, possibly via the inhalatory route, providing mechanistic linkage between man-made air pollution and human airway disease.
Journal ArticleDOI
Immunity to CRISPR Cas9 and Cas12a therapeutics
TL;DR: Ways to assay and reduce the immunogenicity of Cas9 and Cas12a proteins are critical for ensuring patient safety and treatment efficacy, and for bringing us closer to realizing the vision of permanent genetic cures.