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Elizabeth Y Wu
Researcher at Harvard University
Publications - 5
Citations - 2769
Elizabeth Y Wu is an academic researcher from Harvard University. The author has contributed to research in topics: Myocyte & Genome editing. The author has an hindex of 4, co-authored 5 publications receiving 2337 citations. Previous affiliations of Elizabeth Y Wu include Joslin Diabetes Center.
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Journal ArticleDOI
In vivo gene editing in dystrophic mouse muscle and muscle stem cells
Mohammadsharif Tabebordbar,Kexian Zhu,Jason Cheng,Wei Leong Chew,Jeffrey J. Widrick,Winston X. Yan,Winston X. Yan,Claire Maesner,Elizabeth Y Wu,Ru Xiao,F. Ann Ran,F. Ann Ran,Le Cong,Le Cong,Feng Zhang,Feng Zhang,Luk H. Vandenberghe,George M. Church,Amy J. Wagers +18 more
TL;DR: In this paper, the authors developed and tested a direct gene-editing approach to induce exon deletion and recover dystrophin expression in the mdx mouse model of Duchenne muscular dystrophy.
In vivo gene editing in dystrophic mouse muscle and muscle stem cells
Mohammadsharif Tabebordbar,Kexian Zhu,Jason Cheng,Wei Leong Chew,Jeffrey J. Widrick,Claire Maesner,Elizabeth Y Wu,Ru Xiao,Fei Ran,Luk H. Vandenberghe,George M. Church,Amy J. Wagers,Winston X. Yan,Le Cong,Feng Zhang +14 more
TL;DR: A direct gene-editing approach is developed and tested to induce exon deletion and recover dystrophin expression in the mdx mouse model of DMD and partially recovered muscle functional deficiencies and generated a pool of endogenously corrected myogenic precursors in m dx mouse muscle.
Journal ArticleDOI
Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle
Manisha Sinha,Young C. Jang,Young C. Jang,Juhyun Oh,Juhyun Oh,Danika Mei Po Khong,Danika Mei Po Khong,Elizabeth Y Wu,Elizabeth Y Wu,Rohan Manohar,Rohan Manohar,Christine M. Miller,Christine M. Miller,Samuel G. Regalado,Samuel G. Regalado,Francesco S. Loffredo,Francesco S. Loffredo,James R. Pancoast,James R. Pancoast,Michael F. Hirshman,Jessica Lebowitz,Jessica Lebowitz,Jennifer L. Shadrach,Jennifer L. Shadrach,Jennifer L. Shadrach,Massimiliano Cerletti,Massimiliano Cerletti,Mi-Jeong Kim,Thomas Serwold,Laurie J. Goodyear,Laurie J. Goodyear,Bernard Rosner,Richard T. Lee,Richard T. Lee,Amy J. Wagers +34 more
TL;DR: It is demonstrated that the circulating protein growth differentiation factor 11 (GDF11) is a rejuvenating factor for skeletal muscle, and systemically regulates muscle aging and may be therapeutically useful for reversing age-related skeletal muscle and stem cell dysfunction.
Journal ArticleDOI
A multifunctional AAV-CRISPR-Cas9 and its host response
Wei Leong Chew,Mohammadsharif Tabebordbar,Jason Cheng,Prashant Mali,Elizabeth Y Wu,Alex Hay-Man Ng,Kexian Zhu,Amy J. Wagers,George M. Church,George M. Church +9 more
TL;DR: The results reveal that AAV–CRISPR–Cas9 evokes host responses with distinct cellular and molecular signatures, but unlike alternative delivery methods, does not induce extensive cellular damage in vivo.
Journal ArticleDOI
A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice
Colleen Carmody,Ashley N. Ogawa-Wong,Cecilia Martin,Cristina Luongo,Cristina Luongo,Marian J. Zuidwijk,Benjamin Sager,Travis Petersen,Adriana Roginski Guetter,Rob Janssen,Elizabeth Y Wu,Sylvia Bogaards,Neil M. Neumann,Kaman Hau,Alessandro Marsili,Anita Boelen,J. Enrique Silva,J. Enrique Silva,Monica Dentice,Domenico Salvatore,Amy J. Wagers,P. Reed Larsen,Warner S. Simonides,Ann Marie Zavacki +23 more
TL;DR: The results indicate that D2 loss leads to significant changes in soleus contractile function and fiber type composition that are inconsistent with local hypothyroidism and suggest that reduced levels of PCG-1α may contribute to the observed phenotypical changes.