K
KH Chan
Researcher at University of Hong Kong
Publications - 37
Citations - 5380
KH Chan is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Antigen & Randomized controlled trial. The author has an hindex of 13, co-authored 37 publications receiving 4851 citations.
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Journal ArticleDOI
Coronavirus as a possible cause of severe acute respiratory syndrome
Jsm Peiris,Sik To Lai,Llm Poon,Yi Guan,Lyc Yam,Wilina Lim,John M. Nicholls,Wks Yee,WW Yan,MT Cheung,V. C. C. Cheng,KH Chan,Dnc Tsang,R Yung,Ting Kin Ng,KY Yuen +15 more
TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.
Journal ArticleDOI
Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003
Nanshan Zhong,Bo-Jian Zheng,Yimin Li,Leo L.M. Poon,Z. H. Xie,KH Chan,Philip H. Li,S. Y. Tan,Qingsong Chang,J. P. Xie,X. Q. Liu,J. Xu,D. X. Li,Kwok-Yung Yuen,Joseph S. M. Peiris,Yi Guan +15 more
TL;DR: Genetic analysis showed that the SARS CoV isolates from Guangzhou shared the same origin with those in other countries, and had a phylogenetic pathway that matched the spread of SARS to the other parts of the world.
Journal ArticleDOI
Re-emergence of fatal human influenza A subtype H5N1 disease
Jsm Peiris,W C Yu,C W Leung,CY Cheung,Wai F. Ng,John M. Nicholls,Ting Kin Ng,KH Chan,Sik To Lai,W L Lim,Kwok-Yung Yuen,Yi Guan +11 more
TL;DR: Findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease and development of vaccines against influenza A (H5N 1) virus should be made a priority.
Journal ArticleDOI
Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome
Yi Guan,Joseph S. M. Peiris,Bo-Jian Zheng,Leo L.M. Poon,KH Chan,Fanya Zeng,C W M Chan,M N Chan,J D Chen,Ken Y.C. Chow,Chung-Chau Hon,K H Hui,J Li,V Y Y Li,Yixin Wang,Sai-Wing Leung,Kwok-Yung Yuen,Frederick C. Leung +17 more
TL;DR: The molecular epidemiological evidence suggests that most SARS-CoV from the outbreak in Hong Kong, as well as the viruses from Canada, Vietnam, and Singapore, are genetically closely linked.
Journal ArticleDOI
Laboratory markers of tumor burden in nasopharyngeal carcinoma: a comparison of viral load and serologic tests for Epstein-Barr virus.
Hongxin Fan,John M. Nicholls,Daniel Chua,KH Chan,Jonathan S.T. Sham,Shuko Lee,Margaret L. Gulley +6 more
TL;DR: EBV viral load was more informative than was EA serology for distinguishing remission from relapsed disease, and EBV DNA measurement appears to be a noninvasive way to monitor tumor burden after therapy.