K
Khalid Hilmi
Researcher at McGill University
Publications - 5
Citations - 326
Khalid Hilmi is an academic researcher from McGill University. The author has contributed to research in topics: Promoter & Regulation of gene expression. The author has an hindex of 5, co-authored 5 publications receiving 270 citations. Previous affiliations of Khalid Hilmi include Université de Montréal.
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Journal ArticleDOI
Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential
TL;DR: Five most logical molecular mechanisms that may account for the epigenetic silencing of tumor suppressor genes are described, and clinical efforts to target these processes are described.
Journal ArticleDOI
Genome-wide targeting of the epigenetic regulatory protein CTCF to gene promoters by the transcription factor TFII-I
Rodrigo Peña-Hernández,Maud Marques,Khalid Hilmi,Teijun Zhao,Amine Saad,Moulay A. Alaoui-Jamali,Sonia V. del Rincón,Todd Ashworth,Ananda L. Roy,Beverly M. Emerson,Michael Witcher +10 more
TL;DR: Evidence is described that the transcription factor general transcription factor II-I (TFII-I) targets CTCF binding to metabolism-related genes across the genome and regulates the transcription of genes within this network on the level of initiation via RNA polymerase II phosphorylation.
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Nrf2 Transcription Factor Can Directly Regulate mTOR: LINKING CYTOPROTECTIVE GENE EXPRESSION TO A MAJOR METABOLIC REGULATOR THAT GENERATES REDOX ACTIVITY.
TL;DR: Together, data show for the first time that Nrf2 directly regulates mTOR transcription when the PI3K pathway is intact, whereas this function is lost whenPI3K is activated.
Journal ArticleDOI
Raloxifene and ICI182,780 increase estrogen receptor-α association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12
Mathieu Lupien,M. Jeyakumar,M. Jeyakumar,Elise Hébert,Khalid Hilmi,David Cotnoir-White,Caroline Loch,Anick Auger,Guila Dayan,Geneviève Anne Pinard,Jean Marie Wurtz,Dino Moras,John A. Katzenellenbogen,Sylvie Mader,Sylvie Mader +14 more
TL;DR: The data indicate that ICI182,780 and Ral locally alter the ERalpha ligand binding structure via specific hydrophobic residues of H12 and decrease its transcriptional activity through tighter association with an insoluble nuclear structure.
Journal ArticleDOI
Role of SUMOylation in Full Antiestrogenicity
Khalid Hilmi,Nader Hussein,Rodrigo Mendoza-Sanchez,Mohamed El-Ezzy,Houssam Ismail,Chantal Durette,Martine Bail,Maria Johanna Rozendaal,Michel Bouvier,Pierre Thibault,James L. Gleason,Sylvie Mader +11 more
TL;DR: It is reported that SERDs induce the rapid and strong SUMOylation of ERα in ERα-positive and -negative cell lines, including HepG2 cells, which indicates that ERα SUMoylation contributes to full antiestrogenicity in the absence of accelerated receptor turnover.