K
Kheng-Wei Yeoh
Publications - 2
Citations - 276
Kheng-Wei Yeoh is an academic researcher. The author has contributed to research in topics: Natural killer T cell & JAK-STAT signaling pathway. The author has an hindex of 2, co-authored 2 publications receiving 222 citations.
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Journal ArticleDOI
Janus Kinase 3–Activating Mutations Identified in Natural Killer/T-cell Lymphoma
Ghee Chong Koo,Soo Yong Tan,Tiffany Tang,Song Ling Poon,George E. Allen,Leonard Tan,Soo Ching Chong,Whee Sze Ong,Kevin Tay,Miriam Tao,Richard Quek,Susan Loong,Kheng-Wei Yeoh,Swee Peng Yap,Kuo Ann Lee,Lay Cheng Lim,Daryl Tan,Christopher Goh,Ioana Cutcutache,Willie Yu,Cedric Chuan Young Ng,Vikneswari Rajasegaran,Hong Lee Heng,Anna Gan,Choon Kiat Ong,Steve Rozen,Patrick Tan,Bin Tean Teh,Soon Thye Lim +28 more
TL;DR: Functional characterization of the JAK3 mutations support its involvement in cytokine-independent JAK/STAT constitutive activation leading to increased cell growth, and targeting the deregulated Jak/STAT pathway could be a promising therapy for patients with NKTCLs.
Journal ArticleDOI
Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations
Guo-Wang Lin,Guo-Wang Lin,Caigang Xu,Kexin Chen,Hui-Qiang Huang,Jieping Chen,Bao Song,John K.C. Chan,Wenyu Li,Weiping Liu,Shih Ly,Shih Ly,Wen-Yu Chuang,Won Seog Kim,Wen Tan,Rou-Jun Peng,Yurike Laurensia,Daryl Ming Zhe Cheah,Dachuan Huang,Chee Leong Cheng,Yi-Jiun Su,Soo Yong Tan,Siok Bian Ng,Siok Bian Ng,Tiffany Tang,Kyudong Han,Vivien Ya-Fan Wang,Wei Hua Jia,Zhong Pei,Ya-Jun Li,Song Gao,Yongyong Shi,Yongyong Shi,Zhibin Hu,Furen Zhang,Ben Zhang,Yi Xin Zeng,Hongbing Shen,Lin He,Lin He,Choon Kiat Ong,Choon Kiat Ong,Soon Thye Lim,Stephen J. Chanock,Yok-Lam Kwong,Dongxin Lin,Dongxin Lin,Nathaniel Rothman,Chiea Chuen Khor,Chiea Chuen Khor,Qing Lan,Jin-Xin Bei,Wing-Yan Au,Brian C.-H. Chiu,Lei Fan,Zheng Li,Tai Hing Lam,Raymond Liang,Su-Peng Yeh,Jun Xu,Dennis K. M. Ip,Gandi Li,Gang Xu,Xiaodong Wang,Ou Bai,Qingqing Cai,Yi Xia,Jie-Rong Chen,Chun-Ling Luo,Xiang-Yu Xiong,Yanni Zeng,Pan-Pan Wei,Chu-Jun Liu,Yu-Xiang Liu,Yu-Lu Cao,Shuai He,Yang Liu,Jeslin Chian Hung Ha,Lay Poh Khoo,Rebecca Xiangpin Kee,Jing Tan,Yan Hui Liu,Fen Zhang,Yanfen Feng,Huilan Rao,Wee Joo Chng,Jason Yongsheng Chan,Nagavalli D,O Somasundaram,Miriam Tao,Mohamad Farid Bin Harunal Ras,Kheng-Wei Yeoh,Yeow Tee Goh,Shin Yeu Ong,Nicholas Francis Grigoropoulos,Esther Kam Yin Wong,Jane Wan Lu Pang,Jing Quan Lim,Burton Kuan Hui Chia,Seok Kim,Sang Eun Yoon,Seungkyu Choi,Ching-Yuan Kuo,Tsai Yun Chen,Yu-Chieh Su,Wen-Tsung Huang,Ming-Yang Lee,Wenxiu Yao,Kai-Cheong Ngan,Herman Liu,Harold Lee,Sze-Fai Yip,Jie Liu,Jianyong Li,Charles S. Rabkin,Sonja I. Berndt,Bryan A. Bassig,Wei Hu,Mingfeng Zhao,Yuming Li,Qiongli Zhai,Zonghong Shao,Lugui Qiu,Jianxiang Wang,Fu-Ping Xu,Ling Chen,Yu Hou,Shuangnian Xu,Zhen Huang,Mingling Xie,Ming Li,Shilong Zhong,Yan Zhang,Dongqing Gu,Xin Wang,Jia Nee Foo,Zhiqiang Li,Juncheng Dai,Liangdan Sun,Zhenzhen Wang,Hong Liu,Hui Zhou,Yonghu Sun,Woon-Puay Koh,Chew-Kiat Heng,Chew Soo Hong,Jeeyun Ahn,Kyu Hyung Park,Aung Tin,Jieruo Gu,Xiaojun Xia,Bo Li,Xueqing Yu +152 more
TL;DR: The findings provide new insights into the development of NKTCL by showing the importance of inflammation and immune regulation through the IL18-IL18RAP axis and antigen presentation involving HLA-DRB1, which might help to identify potential therapeutic targets.