Burton Kuan Hui Chia

TL;DR: The Critical Assessment of Metagenome Interpretation (CAMI) challenge has engaged the global developer community to benchmark their programs on highly complex and realistic data sets, generated from ∼700 newly sequenced microorganisms and ∼600 novel viruses and plasmids and representing common experimental setups as discussed by the authors.

TL;DR: It is demonstrated that STAT3 activation confers high PD-L1 expression, which may promote tumor immune evasion and the combination of PD-1/PD-L 1 antibodies and STAT3 inhibitors might be a promising therapeutic approach for NKTL, and possibly PTCL.

TL;DR: This work computationally predicted and experimentally validated the gene TRIM24 as a putative novel amplified driver in a melanoma patient and provides the first demonstration that computationally derived driver mutation signatures can be overall superior to single gene and gene expression based signatures in enabling patient stratification and prognostication.

TL;DR: Global mutational and transcriptional profiles of EBV in NKTCL clinical samples are reported for the first time, revealing important somatic events ofEBV and providing insights to better understanding of EBv’s contribution in tumorigenesis.

TL;DR: OPERA-LG is a scalable, exact algorithm for the scaffold assembly of large, repeat-rich genomes, out-performing state-of-the-art programs for scaffold correctness and contiguity.