K
Kieran McCafferty
Researcher at Barts Health NHS Trust
Publications - 53
Citations - 647
Kieran McCafferty is an academic researcher from Barts Health NHS Trust. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 31 publications receiving 392 citations. Previous affiliations of Kieran McCafferty include Royal London Hospital & Queen Mary University of London.
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Journal ArticleDOI
The challenge of translating ischemic conditioning from animal models to humans: the role of comorbidities
TL;DR: The experimental technique of ischemic conditioning, which entails exposing organs or tissues to brief sub-lethal episodes of ischemia and reperfusion, before, during or after a lethal isChemic insult, is examined and found to confer profound tissue protection against IRI.
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Extracellular volume expansion, measured by multifrequency bioimpedance, does not help preserve residual renal function in peritoneal dialysis patients
TL;DR: This study does not support the view that overhydration preserves residual renal function and such a policy risks the consequences of persistent hypervolemia.
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A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study of Sodium Zirconium Cyclosilicate for Reducing the Incidence of Predialysis Hyperkalemia.
Steven Fishbane,Martin Ford,Masafumi Fukagawa,Kieran McCafferty,Anjay Rastogi,Bruce Spinowitz,Konstantin Staroselskiy,Konstantin Vishnevskiy,Vera Lisovskaja,Ayman Al-Shurbaji,Nicolas Guzman,Sunil Bhandari +11 more
TL;DR: Sodium zirconium cyclosilicate is an effective and well-tolerated treatment for predialysis hyperkalemia in patients with ESRD undergoing adequate hemodialysis.
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Finerenone in Predominantly Advanced CKD and Type 2 Diabetes With or Without Sodium-Glucose Cotransporter-2 Inhibitor Therapy
Peter Rossing,Peter Rossing,Gerasimos Filippatos,Rajiv Agarwal,Stefan D. Anker,Bertram Pitt,Luis M. Ruilope,Juliana C.N. Chan,Adriaan Kooy,Kieran McCafferty,Guntram Schernthaner,Christoph Wanner,Amer Joseph,Markus F. Scheerer,Charlie Scott,George L. Bakris,Fidelio-Dkd Investigators +16 more
TL;DR: UACR improvement was observed with finerenone in patients with CKD and T2D already receiving SGLT-2is at baseline, and benefits on kidney and cardiovascular outcomes appear consistent irrespective of use of SGLt-2i.
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Ischemic Conditioning Protects the Uremic Heart in a Rodent Model of Myocardial Infarction
Conor J. Byrne,Kieran McCafferty,Julius Kieswich,Steven Harwood,Petros Andrikopoulos,Martin Raftery,Christoph Thiemermann,Muhammad M. Yaqoob +7 more
TL;DR: Analysis of the signaling mechanisms revealed that components of both the reperfusion injury salvage kinase and survivor activating factor enhancement pathways were similarly upregulated in both uremic and nonuremic animals after an IPC stimulus.