K
Kim Boekelheide
Researcher at Brown University
Publications - 201
Citations - 12333
Kim Boekelheide is an academic researcher from Brown University. The author has contributed to research in topics: Sertoli cell & Germ cell. The author has an hindex of 56, co-authored 200 publications receiving 11531 citations. Previous affiliations of Kim Boekelheide include Duke University & Butler Hospital.
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Journal ArticleDOI
From the Cover: Sperm Molecular Biomarkers Are Sensitive Indicators of Testicular Injury following Subchronic Model Toxicant Exposure.
TL;DR: Results suggest that sperm mRNA transcripts are sensitive indicators of low dose toxicant-induced testicular injury in the rat, while sperm DNA methylation changes are not.
Journal ArticleDOI
Intra‐ and inter‐individual differences in human sperm DNA methylation
Edward Dere,Susan M. Huse,Kathleen Hwang,Kathleen Hwang,Mark Sigman,Mark Sigman,Kim Boekelheide +6 more
TL;DR: The intra‐individual methylation levels were more highly correlated than the inter‐individual comparison both globally and across the defined genomic regions, demonstrating that sperm DNA methylation Levels are relatively stable between semen sample collections.
Book ChapterDOI
Spermatogenesis by Sisyphus: proliferating stem germ cells fail to repopulate the testis after 'irreversible' injury
TL;DR: Interestingly, this persistent state of post-injury 'irreversible' atrophy in the rat is characterized by the presence of a proliferating stem germ cell population which produces differentiating spermatogonia which then die by apoptosis.
Journal ArticleDOI
γ-Tubulin Overexpression in Sertoli Cells In Vivo: I. Localization to Sites of Spermatid Head Attachment and Alterations in Sertoli Cell Microtubule Distribution
TL;DR: To evaluate the importance of Sertoli cell microtubule-based activities for spermatogenesis, an adenoviral vector that overexpresses the microtubules nucleating protein, γ-tubulin, was used to selectively disruptmicrotubule networks in SERToli cells in vivo.
Journal ArticleDOI
Assuring safety without animal testing: the case for the human testis in vitro.
Robert E. Chapin,Kim Boekelheide,Rita Cortvrindt,Majorie B.M. van Duursen,Timothy W. Gant,Bernard Jégou,Emma L. Marczylo,Ans M.M. van Pelt,Janine N. Post,Maarke J.E. Roelofs,Stefan Schlatt,Katja J. Teerds,Jorma Toppari,Aldert H. Piersma +13 more
TL;DR: The workshop recognized the specific complexity of testicular function exemplified by dedicated cell types with distinct functionalities, as well as different cell compartments in terms of microenvironment and extracellular matrix components, which hampers quick results in the realm of alternative models.