K
Kimberly J. Briggs
Researcher at Johns Hopkins University
Publications - 10
Citations - 2068
Kimberly J. Briggs is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cancer & Cancer research. The author has an hindex of 5, co-authored 6 publications receiving 1984 citations.
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Journal ArticleDOI
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
David M. Berman,Sunil S. Karhadkar,Anirban Maitra,Rocío Montes de Oca,Meg R. Gerstenblith,Kimberly J. Briggs,Antony R. Parker,Yutaka Shimada,James R. Eshleman,D. Neil Watkins,Philip A. Beachy +10 more
TL;DR: A wide range of digestive tract tumours, including most of those originating in the oesophagus, stomach, biliary tract and pancreas, but not in the colon, display increased Hh pathway activity, which is suppressible by cyclopamine, a Hh pathways antagonist.
Journal ArticleDOI
Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
Silvia Buonamici,Juliet Williams,Michael Morrissey,Anlai Wang,Ribo Guo,Anthony Vattay,Kathy Hsiao,Jing Yuan,John Green,Beatriz Ospina,Qunyan Yu,Lance Ostrom,Paul Fordjour,Dustin L. Anderson,John Monahan,Joseph Kelleher,Stefan Peukert,Shifeng Pan,Xu Wu,Sauveur Michel Maira,Carlos Garcia-Echeverria,Kimberly J. Briggs,D. Neil Watkins,Yung Mae Yao,Christoph Lengauer,Markus Warmuth,William R. Sellers,Marion Dorsch +27 more
TL;DR: By identifying a drug combination that delays or even combats development of resistance when used as a first-line treatment in clinical trials, these results could ultimately improve the lives of patients with medulloblastoma or other cancers that depend on Smo for their survival.
Journal ArticleDOI
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.
Kimberly J. Briggs,Ian M. Corcoran-Schwartz,Wei Zhang,Thomas Harcke,Wendy Devereux,Stephen B. Baylin,Charles G. Eberhart,D. Neil Watkins +7 more
TL;DR: It is shown that Hic1 is a direct transcriptional repressor of Atonal Homolog 1 (Atoh1), a proneural transcription factor essential for cerebellar development, and that ATOH1 expression is required for human medulloblastoma cell growth in vitro.
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Cancer-Related Epigenome Changes Associated with Reprogramming to Induced Pluripotent Stem Cells
Joyce E. Ohm,Joyce E. Ohm,Prashant Mali,Leander Van Neste,David M. Berman,Liang Liang,Kurinji Pandiyan,Kimberly J. Briggs,Wei Zhang,Pedram Argani,Brian W. Simons,Wayne Yu,William Matsui,Wim Van Criekinge,Feyruz V. Rassool,Elias T. Zambidis,Kornel E. Schuebel,Leslie Cope,Jonathan Yen,Helai P. Mohammad,Linzhao Cheng,Stephen B. Baylin +21 more
TL;DR: By studying the process of induced reprogramming, this work suggests that it may gain significant insight into the origins of epigenetic gene silencing associated with human tumorigenesis, and add to means of assessing iPS for safety.
Journal ArticleDOI
Just Say No to ATOH: How HIC1 Methylation Might Predispose Medulloblastoma to Lineage Addiction
TL;DR: Hypermethylated in cancer-1 (HIC1) is a tumor suppressor frequently targeted for promoter hypermethylation in medulloblastoma, an embryonal tumor of the cerebellum as discussed by the authors.