Wendy Devereux

TL;DR: Data reveal that Hh pathway activation is heterogeneous across the spectrum of MM tumor stem cells and their more differentiated progeny, and that the potential existence of similar relationships in other adult cancers may have important biologic and clinical implications for the study of aberrant Hh signaling.

TL;DR: A primary xenograft model of small-cell lung cancer is described in which endobronchial tumor specimens obtained from chemo-naive patients are serially propagated in vivo in immunodeficient mice to identify a group of tumor-specific genes expressed in primary SCLC and Xenografts that was lost during the transition to tissue culture and that was not regained when the tumors were reestablished as secondary xenografteds.

TL;DR: Findings show a crucial cell-intrinsic role for Hedgehog signaling in the development and maintenance of SCLC and identify Hedgehog pathway inhibition as a therapeutic strategy to slow the progression of disease and delay cancer recurrence in individuals with S CLC.

TL;DR: The cloning and initial characterization of human PAO and results demonstrate that in at least one cell type, PAO is up-regulated in response to polyamine analogue exposure.

TL;DR: The results of these studies are consistent with the hypothesis that PAOh1/SMO represents a new addition to the polyamine metabolic pathway that may represent a new target for antineoplastic drug development.