K
Kjetil Taskén
Researcher at Oslo University Hospital
Publications - 287
Citations - 16023
Kjetil Taskén is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Protein kinase A & T cell. The author has an hindex of 62, co-authored 279 publications receiving 14800 citations. Previous affiliations of Kjetil Taskén include Norwegian Institute of Public Health & University of Oslo.
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Journal ArticleDOI
Localized Effects of cAMP Mediated by Distinct Routes of Protein Kinase A
TL;DR: Targeting of PKA and integration of a wide repertoire of proteins involved in signal transduction into complex signal networks further increase the specificity required for the precise regulation of numerous cellular and physiological processes.
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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
Torkel Vang,Mauro Congia,Maria Doloretta Macis,Lucia Musumeci,Valeria Orrù,Valeria Orrù,Patrizia Zavattari,Konstantina Nika,Lutz Tautz,Kjetil Taskén,Francesco Cucca,Francesco Cucca,Tomas Mustelin,Nunzio Bottini,Nunzio Bottini +14 more
TL;DR: It is concluded that the autoimmune-predisposing allele of the gene PTPN22 is a gain-of-function mutant.
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Specificity in the cAMP/PKA signaling pathway. differential expression, regulation, and subcellular localization of subunits of PKA.
TL;DR: Features of PKA signaling pathway are described that may contribute to explain how differential effects of cAMP may be maintained in this pathway.
Journal ArticleDOI
FOXC2 Is a Winged Helix Gene that Counteracts Obesity, Hypertriglyceridemia, and Diet-Induced Insulin Resistance
TL;DR: Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity, including hypertriglyceridemia and diet-induced insulin resistance, and a likely consequence hereof would be protection against type 2 diabetes.
Journal ArticleDOI
Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
Torkel Vang,Knut Martin Torgersen,Vibeke Sundvold,Manju Saxena,Finn Olav Levy,Bjørn Steen Skålhegg,Vidar Hansson,Tomas Mustelin,Tomas Mustelin,Kjetil Taskén +9 more
TL;DR: A mechanism whereby PKA through activation of Csk intersects signaling by Src kinases and inhibits T cell activation is proposed, which leads to a two- to fourfold increase in Csk activity that is necessary for cAMP-mediated inhibition of TCR-induced interleukin 2 secretion.