V
Valeria Orrù
Researcher at University of Southern California
Publications - 40
Citations - 2324
Valeria Orrù is an academic researcher from University of Southern California. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 15, co-authored 31 publications receiving 1938 citations. Previous affiliations of Valeria Orrù include University of Cagliari.
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Journal ArticleDOI
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
Torkel Vang,Mauro Congia,Maria Doloretta Macis,Lucia Musumeci,Valeria Orrù,Valeria Orrù,Patrizia Zavattari,Konstantina Nika,Lutz Tautz,Kjetil Taskén,Francesco Cucca,Francesco Cucca,Tomas Mustelin,Nunzio Bottini,Nunzio Bottini +14 more
TL;DR: It is concluded that the autoimmune-predisposing allele of the gene PTPN22 is a gain-of-function mutant.
Journal ArticleDOI
Genetic variants regulating immune cell levels in health and disease
Valeria Orrù,Maristella Steri,Gabriella Sole,Carlo Sidore,Carlo Sidore,Francesca Virdis,Mariano Dei,Sandra Lai,Magdalena Zoledziewska,Fabio Busonero,Antonella Mulas,Matteo Floris,Wieslawa I. Mentzen,Silvana Anna Maria Urru,Stefania Olla,Michele Marongiu,Maria Grazia Piras,Monia Lobina,Andrea Maschio,Maristella Pitzalis,Maria Francesca Urru,Marco Marcelli,Roberto Cusano,Francesca Deidda,Valentina Serra,Manuela Oppo,Rosella Pilu,Frederic Reinier,Riccardo Berutti,Luca Pireddu,Ilenia Zara,Eleonora Porcu,Alan Kwong,Christine Brennan,Brendan Tarrier,Robert H. Lyons,Hyun Min Kang,Sergio Uzzau,Rossano Atzeni,M. Valentini,Davide Firinu,Lidia Leoni,Gianluca Rotta,Silvia Naitza,Andrea Angius,Mauro Congia,Michael B. Whalen,Chris Jones,David Schlessinger,Gonçalo R. Abecasis,Edoardo Fiorillo,Serena Sanna,Francesco Cucca +52 more
TL;DR: Genetic contributions to quantitative levels of 95 cell types encompassing 272 immune traits, in a cohort of 1,629 individuals from four clustered Sardinian villages are reported, connecting specific cellular phenotypes to specific genetic variants, helping to explicate their involvement in disease.
Journal ArticleDOI
Overexpression of the Cytokine BAFF and Autoimmunity Risk
Maristella Steri,Valeria Orrù,M. Laura Idda,Maristella Pitzalis,Mauro Pala,Ilenia Zara,Carlo Sidore,Valeria Faà,Matteo Floris,Manila Deiana,Isadora Asunis,Eleonora Porcu,Antonella Mulas,Maria Grazia Piras,Monia Lobina,Sandra Lai,Mara Marongiu,Valentina Serra,Michele Marongiu,Gabriella Sole,Fabio Busonero,Andrea Maschio,Roberto Cusano,Gianmauro Cuccuru,Francesca Deidda,Fausto Pier'Angelo Poddie,Gabriele Farina,Mariano Dei,Francesca Virdis,Stefania Olla,Maria Anna Satta,Mario Pani,Alessandro P Delitala,Eleonora Cocco,Jessica Frau,Giancarlo Coghe,Lorena Lorefice,Giuseppe Fenu,Paola Ferrigno,Maria Ban,N. Barizzone,Maurizio Leone,Franca Rosa Guerini,Matteo Piga,Davide Firinu,Ingrid Kockum,Izaura Lima Bomfim,Tomas Olsson,Lars Alfredsson,Lars Alfredsson,Ana Suárez,Patricia Carreira,Maria J. Castillo-Palma,Joseph Marcus,Mauro Congia,Andrea Angius,Maurizio Melis,Antonio Gonzalez,Marta E. Alarcón Riquelme,Berta M. da Silva,Maurizio Marchini,Maria Giovanna Danieli,Stefano Del Giacco,Alessandro Mathieu,Antonello Pani,Stephen B. Montgomery,Giulio Rosati,Jan Hillert,Stephen Sawcer,Sandra D'Alfonso,John A. Todd,John Novembre,Gonçalo R. Abecasis,Michael B. Whalen,Maria Giovanna Marrosu,Alessandra Meloni,Serena Sanna,Myriam Gorospe,David Schlessinger,Edoardo Fiorillo,Magdalena Zoledziewska,Francesco Cucca +81 more
TL;DR: A TNFSF13B variant was associated with multiple sclerosis and SLE, and its effects were clarified at the population, cellular, and molecular levels.
Journal ArticleDOI
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus
Valeria Orrù,Sophia J. Tsai,Blanca Rueda,Edoardo Fiorillo,Stephanie M. Stanford,Jhimli Dasgupta,Jaana Hartiala,Lei Zhao,Norberto Ortego-Centeno,Sandra D'Alfonso,Frank C. Arnett,Hui Wu,Miguel A. González-Gay,Betty P. Tsao,Bernardo A. Pons-Estel,Marta E. Alarcón-Riquelme,Yantao He,Zhong Yin Zhang,Hooman Allayee,Xiaojiang S. Chen,Javier Martin,Nunzio Bottini +21 more
TL;DR: High-resolution structural analysis revealed the molecular basis for this loss of function in the PTPN22 gene, and the Q263 variant conferred protection against human systemic lupus erythematosus, reinforcing the proposal that inhibition of LYP activity could be beneficial in human autoimmunity.
Journal ArticleDOI
Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study
Divya Krishnamurthy,Mark R. Karver,Edoardo Fiorillo,Valeria Orrù,Stephanie M. Stanford,Nunzio Bottini,Amy M. Barrios +6 more
TL;DR: Gold(I) complexes containing N-heterocyclic carbene ligands were synthesized, characterized, and along with the antiarthritic drug, auranofin, tested as inhibitors of the cysteine-dependent protein tyrosine phosphatases, which are implicated in several disease states.