Klára Kirsch

TL;DR: It is proposed that short MAPK‐binding stretches are created in disordered protein segments through a variety of ways and they represent a major resource for ancient signaling enzymes to acquire new regulatory roles.

TL;DR: Since cold acclimation induced the accumulation of most of the amino acids, while ABA had a significant effect only on Asn, the cold-induced changes in free amino acid levels were probably not mediated by ABA.

TL;DR: It is shown that the ATF2 TAD is controlled by functionally distinct signaling pathways (JNK and p38) through structurally different MAPK binding sites, andStructures of MAPK-TAD complexes and mechanistic modeling of ATF1 TAD phosphorylation in cells suggest that kinase binding motifs and phosphorylated sites line up to maximize MAPK based co-regulation.

TL;DR: It is shown that free amino acids and polyamines play an important role in the cold acclimation and their levels are regulated at the transcriptional level.

TL;DR: It is identified that kinase heterodimers form structurally and functionally distinct complexes depending on the activation state of the MAPK, and it is shown that small-molecule inhibitors may affect the quaternary arrangement of kinase heterogeneity and thus influence downstream signaling in a specific manner.