Klaus Seppi

TL;DR: The majority (n = 17, 61%) who scored positive for RLS reported that the urge to move the legs and unpleasant sensations were associated with wearing off, raising the possibility of RLS mimics in fluctuating patients with PD.

TL;DR: Newborn screening for the cblC defect might be of benefit especially for late-onset patients since treatment seems efficient when initiated before irreversible organ damage and in general, inborn errors of metabolisms should be considered in unexplained medical cases at any age, especially in patients with multisystemic disease.

TL;DR: The European Huntington's Disease Network (EHDN) commissioned an international task force to provide global evidence-based recommendations for everyday clinical practice for treatment of Huntington's disease to standardize pharmacological, surgical and non-pharmacological treatment regimen and improve care and quality of life of patients.

TL;DR: This article focuses on static or structural conventional MR imaging techniques including standard T2-weighted, T1- weighted, and proton-density sequences, as well as different advanced techniques, including methods to assess regional cerebral atrophy quantitatively such as magnetic resonance volumetry, diffusion tensor and diffusion- Weighted imaging, and magnetization transfer imaging, to assist in the differential diagnosis of neurodegenerative parkinsonian disorders.

TL;DR: The preponderance of reduced left putaminal dopamine transporter availability strengthens clinical observations of a greater proportion of right-handed patients with Parkinson's disease with predominantly right-sided motor signs and argues against a randomly distributed asymmetric vulnerability of substantia nigra dopaminergic neurons.