K
Kleiton Silva Borges
Researcher at University of São Paulo
Publications - 36
Citations - 489
Kleiton Silva Borges is an academic researcher from University of São Paulo. The author has contributed to research in topics: DNA methylation & Cell growth. The author has an hindex of 13, co-authored 28 publications receiving 363 citations. Previous affiliations of Kleiton Silva Borges include University of California, Los Angeles & Harvard University.
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Journal ArticleDOI
Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells
Kleiton Silva Borges,Angel Mauricio Castro-Gamero,Daniel Antunes Moreno,Vanessa da Silva Silveira,María Sol Brassesco,Rosane Gomes de Paula Queiroz,Harley Francisco de Oliveira,Carlos Gilberto Carlotti,Carlos Alberto Scrideli,Luiz Gonzaga Tone +9 more
TL;DR: The data suggest that Aurora kinase inhibition may be a target for glioblastoma treatment and could be used as adjuvant to chemo- and radiotherapy.
Journal ArticleDOI
Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation
Emanuele Pignatti,Emanuele Pignatti,Sining Leng,Sining Leng,Yixing Yuchi,Yixing Yuchi,Kleiton Silva Borges,Kleiton Silva Borges,Nick A. Guagliardo,Manasvi S. Shah,Manasvi S. Shah,Gerard Ruiz-Babot,Gerard Ruiz-Babot,Dulanjalee Kariyawasam,Dulanjalee Kariyawasam,Makoto Mark Taketo,Ji Miao,Ji Miao,Paula Q. Barrett,Diana L. Carlone,Diana L. Carlone,David T. Breault,David T. Breault +22 more
TL;DR: It is found that β-catenin drives adrenal hyperplasia through both proliferation-dependent and -independent mechanisms, and is further exacerbated by trophic factor stimulation leading to organomegaly.
Journal ArticleDOI
Antiproliferative effects of Tubi-bee propolis in glioblastoma cell lines
Kleiton Silva Borges,María Sol Brassesco,Carlos Alberto Scrideli,Ademilson Espencer Egea Soares,Luiz Gonzaga Tone +4 more
TL;DR: Evaluated in vitro the Tubi-bee propolis effects on human glioblastoma and fibroblast cell lines showed an antiproliferative effect of tubi-bees propolis against gliobeasts, and combination of propolis with TMZ had a synergic anti-proliferative effects.
Journal ArticleDOI
Purification and Biochemical Characterization of Native and Pegylated Form of L-Asparaginase from Aspergillus terreus and Evaluation of Its Antiproliferative Activity
Claudio Battiston Loureiro,Kleiton Silva Borges,Augusto Faria Andrade,Luiz Gonzaga Tone,Suraia Said +4 more
TL;DR: For the first time, an L-asparaginase from fungus was evaluated as an antitumor agent in human cells lines and further investigations should be conducted to improve the knowledge about this enzyme.
Journal ArticleDOI
Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells.
Augusto Faria Andrade,Kleiton Silva Borges,Angel Mauricio Castro-Gamero,Vanessa da Silva Silveira,Veridiana K. Suazo,Jaqueline Carvalho de Oliveira,Daniel Antunes Moreno,Rosane Gomes de Paula Queiroz,Carlos Alberto Scrideli,Luiz Gonzaga Tone +9 more
TL;DR: Evaluated effects of ZB on childhood ALL cell lines indicate that ZB may be a promising drug for the adjuvant treatment of ALL, mainly when combined with methotrexate.