Sining Leng

TL;DR: It is reported that insulin sensitivity in the white adipose tissue of LDKO mice is also impaired but is restored in LTKO mice in conjunction with normal suppression of HGP by insulin, and excess follistatin (Fst) is a pathological hepatokine that might be targeted for diabetes therapy during hepatic insulin resistance.

TL;DR: It is demonstrated that within the rosette, angiotensin II evokes periodic Ca v 3-dependent calcium events that form bursts that are stereotypic in form that define the calcium burst as the fundamental unit of zG layer activity evoked by angiotENSin II and highlight a novel role for the ro sette as a facilitator of cell communication.

TL;DR: This work reviews the distinctions between each zone by highlighting their morphological and ultra-structural features, discusses key signaling pathways influencing zonal identity, and evaluates current evidence for long-term self-renewing stem cells in the adult cortex.

TL;DR: It is found that β-catenin drives adrenal hyperplasia through both proliferation-dependent and -independent mechanisms, and is further exacerbated by trophic factor stimulation leading to organomegaly.

TL;DR: It is shown that rosette formation regulated by β-Catenin and FGFR2 mediate postnatal adrenal cortex zona glomerulosa morphogenesis and is a framework for studying the role of rosettes in adult zonal tissue maintenance and function.