K
Koen van der Maaden
Researcher at Leiden University
Publications - 34
Citations - 1492
Koen van der Maaden is an academic researcher from Leiden University. The author has contributed to research in topics: Drug delivery & Cationic liposome. The author has an hindex of 16, co-authored 34 publications receiving 1147 citations. Previous affiliations of Koen van der Maaden include Leiden University Medical Center.
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Journal ArticleDOI
Microneedle technologies for (trans)dermal drug and vaccine delivery.
TL;DR: This review describes different production methods for solid and hollow microneedles as well as conditions that influence skin penetration and the view on research and development that is needed to rendermicroneedle-based (trans)dermal drug delivery technologies clinically useful in the near future.
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Cationic Liposomes Loaded with a Synthetic Long Peptide and Poly(I:C): a Defined Adjuvanted Vaccine for Induction of Antigen-Specific T Cell Cytotoxicity
TL;DR: Cationic liposomes loaded with SLP and poly(I:C) have potential as a powerful therapeutic cancer vaccine formulation and showed an at least 25 fold increase over the T cell frequency induced by the poly( I:C)-adjuvanted soluble SLP.
Journal ArticleDOI
Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays
Koen van der Maaden,Regina Luttge,Pjw Vos,Joke A. Bouwstra,Gideon F.A. Kersten,Ihj Ingmar Ploemen +5 more
TL;DR: Preliminary data with commercially available porous microneedles is shown and future directions in this field of research are described, which could be a valuable addition to the othermicroneedle-based drug delivery approaches.
Journal ArticleDOI
Layer-by-Layer Assembly of Inactivated Poliovirus and N-Trimethyl Chitosan on pH-Sensitive Microneedles for Dermal Vaccination
Koen van der Maaden,Emine Sekerdag,Pim Schipper,Gideon F.A. Kersten,Wim Jiskoot,Joke A. Bouwstra +5 more
TL;DR: Topical administration of pH-sensitive microneedles coated with polyelectrolyte multinanolayers of antigens and oppositely charged polymers may be a useful approach for micronedle-based vaccination.
Journal ArticleDOI
Novel Hollow Microneedle Technology for Depth-Controlled Microinjection-Mediated Dermal Vaccination: A Study with Polio Vaccine in Rats
Koen van der Maaden,Sebastiaan Johannes Trietsch,Heleen Kraan,Eleni Maria Varypataki,Stefan Romeijn,Raphaël Zwier,Heiko J. van der Linden,Gideon F.A. Kersten,Thomas Hankemeier,Wim Jiskoot,Joke A. Bouwstra +10 more
TL;DR: A hollow microneedle technology for dermal vaccination that enables fundamental research on factors, such as insertion depth and volume, and insertion angle, on the immune response is successfully developed.