Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays
Koen van der Maaden,Regina Luttge,Pjw Vos,Joke A. Bouwstra,Gideon F.A. Kersten,Ihj Ingmar Ploemen +5 more
TLDR
Preliminary data with commercially available porous microneedles is shown and future directions in this field of research are described, which could be a valuable addition to the othermicroneedle-based drug delivery approaches.Abstract:
In the literature, several types of microneedles have been extensively described. However, porous microneedle arrays only received minimal attention. Hence, only little is known about drug delivery via these microneedles. However, porous microneedle arrays may have potential for future microneedle-based drug and vaccine delivery and could be a valuable addition to the other microneedle-based drug delivery approaches. To gain more insight into porous microneedle technologies, the scientific and patent literature is reviewed, and we focus on the possibilities and constraints of porous microneedle technologies for dermal drug delivery. Furthermore, we show preliminary data with commercially available porous microneedles and describe future directions in this field of research.read more
Citations
More filters
Journal ArticleDOI
Polylactic acid (PLA) controlled delivery carriers for biomedical applications.
TL;DR: PLA's application as drug-loaded nanoparticle drug carriers, such as liposomes, polymeric nanoparticles, dendrimers, and micelles, can encapsulate otherwise toxic hydrophobic anti-tumor drugs and evade systemic toxicities.
Journal ArticleDOI
Recent advances of controlled drug delivery using microfluidic platforms.
TL;DR: This article reviews recent advances of controlled drug delivery using microfluidic platforms which can be implanted in human bodies to control drug release in real time through an on‐demand feedback mechanism.
Journal ArticleDOI
3D printing applications for transdermal drug delivery.
TL;DR: The current regulatory framework associated with 3D printed transdermal drug delivery systems is outlined and the range of printable materials that are currently used or potentially can be employed for 3D printing of transder mal drug delivery (TDD) systems is reviewed.
Journal ArticleDOI
Tailoring Porous Silicon for Biomedical Applications : From Drug Delivery to Cancer Immunotherapy
TL;DR: Very promising research results encourage further exploration of porous silicon for biomedical applications, particularly in drug delivery and cancer immunotherapy, and future translation of PSi into clinical applications.
Journal ArticleDOI
Dissolving microneedle patches for dermal vaccination
TL;DR: This review focuses on dissolving microneedles that after penetration into the skin dissolve releasing the encapsulated antigen, and the immunogenicity of antigens formulated in dissolvingmicroneedle are addressed.
References
More filters
Journal ArticleDOI
Microneedles for drug and vaccine delivery.
TL;DR: Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.
Journal ArticleDOI
Microfabricated microneedles: a novel approach to transdermal drug delivery.
TL;DR: These microneedle arrays could be easily inserted into skin without breaking and were shown to increase permeability of human skin in vitro to a model drug, calcein, by up to 4 orders of magnitude.
Patent
Microneedle devices and methods of manufacture and use thereof
TL;DR: In this article, a method for making a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow micromolds, and then removing the micromolding from the micronule, is described.
Journal ArticleDOI
Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies
Devin V. McAllister,Ping M. Wang,Shawn P. Davis,Jung-Hwan Park,Paul J. Canatella,Mark G. Allen,Mark R. Prausnitz +6 more
TL;DR: Microfabrication techniques for silicon, metal, and biodegradable polymer microneedle arrays having solid and hollow bores with tapered and beveled tips and feature sizes from 1 to 1,000 μm allowed flow of microliter quantities into skin in vivo, including microinjection of insulin to reduce blood glucose levels in diabetic rats.
Journal ArticleDOI
Dissolving microneedles for transdermal drug delivery.
TL;DR: It is concluded that dissolving microneedles can be designed to gently encapsulate molecules, insert into skin, and enable bolus or sustained release delivery and leave behind no biohazardous sharp medical waste.