Hollow microneedle-mediated micro-injections of a liposomal HPV E7(43-63) synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses
Koen van der Maaden,Jeroen Heuts,Marcel Camps,Maria Pontier,Anton G. T. Terwisscha van Scheltinga,Wim Jiskoot,Ferry Ossendorp,Joke A. Bouwstra +7 more
TLDR
By using the newly developed DC‐hMN‐iSystem, very low vaccine volumes can be precisely injected into skin in an automated manner, and shows potential for minimally‐invasive and potentially pain‐free therapeutic cancer vaccination.About:
This article is published in Journal of Controlled Release.The article was published on 2018-01-10 and is currently open access. It has received 68 citations till now. The article focuses on the topics: Cancer vaccine & Peptide vaccine.read more
Citations
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Microneedles: A smart approach and increasing potential for transdermal drug delivery system.
Tejashree Waghule,Gautam Singhvi,Sunil Kumar Dubey,Murali Monohar Pandey,Gaurav Gupta,Mahaveer Singh,Kamal Dua +6 more
TL;DR: A new form of delivery system called the microneedles helps to enhance the delivery of the drug through this route and overcoming the various problems associated with the conventional formulations.
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Recent advances of microneedles for biomedical applications: drug delivery and beyond.
TL;DR: In this review, a great effort has been made to summarize the advance of microneedles including their materials and latest fabrication method, such as three-dimensional printing (3DP).
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Intradermal and transdermal drug delivery using microneedles - Fabrication, performance evaluation and application to lymphatic delivery.
Akmal H. Sabri,Yujin Kim,Maria Marlow,David J. Scurr,Joel Segal,Ajay K. Banga,Leonid Kagan,Jong Bong Lee +7 more
TL;DR: As the research expands, it has been observed that therapeutics delivered via microneedles has gained expedited access to the lymphatics, which makes them a favorable delivery method for targeting the lymphatic system.
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Microneedles for transdermal drug delivery: a systematic review.
TL;DR: This review summarizes the types of MNs and fabrication techniques of different types ofMNs and the safety aspects of the materials used for fabrication have been discussed in detail.
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Recent advances in microneedle-based drug delivery: Special emphasis on its use in paediatric population
TL;DR: This review proposes that advanced research can further contribute to the improved therapeutic efficiency of microneedle‐based delivery of numerous molecules, which are otherwise difficult to administer via the conventional transdermal delivery mechanisms.
References
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Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia
Gemma G. Kenter,Marij J. P. Welters,A. Rob P. M. Valentijn,Margriet J. G. Löwik,Dorien M A Berends-van der Meer,Annelies P G Vloon,Farah Essahsah,Lorraine M. Fathers,Rienk Offringa,Jan W. Drijfhout,Amon R. Wafelman,Jaap Oostendorp,Gert Jan Fleuren,Sjoerd H. van der Burg,Cornelis J. M. Melief +14 more
TL;DR: Clinical responses in women with HPV- 16-positive, grade 3 vulvar intraepithelial neoplasia can be achieved by vaccination with a synthetic long-peptide vaccine against the HPV-16 oncoproteins E6 and E7.
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Vaccines for established cancer: overcoming the challenges posed by immune evasion.
TL;DR: How therapeutic benefit can be maximized in patients with established cancers by using vaccines to increase the effects of standard chemotherapies, to establish and/or maintain tumour-specific T cells that are re-energized by checkpoint blockade and other therapies, and to sustain the antitumour response of adoptively transferred T cells is summarized.
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Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines
TL;DR: This Review deals with recent progress in the immunotherapy of established (pre)malignant disease of viral or non-viral origin by synthetic vaccines capable of inducing robust T-cell responses.
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Microneedle technologies for (trans)dermal drug and vaccine delivery.
TL;DR: This review describes different production methods for solid and hollow microneedles as well as conditions that influence skin penetration and the view on research and development that is needed to rendermicroneedle-based (trans)dermal drug delivery technologies clinically useful in the near future.
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Effect of Microneedle Design on Pain in Human Volunteers
TL;DR: Microneedles are significantly less painful than a 26-gauge hypodermic needle over the range of dimensions investigated and decreasing microneedle length and number reduces pain in normal human volunteers.