Kouki Nishikawa

TL;DR: Adult human stem cells that can generate, from a single cell, cells with the characteristics of the three germ layers can be obtained through easily accessible adult human mesenchymal cells without introducing exogenous genes.

TL;DR: Results show that B. salamandrivorans is restricted to, but highly pathogenic for, salamanders and newts (Urodela), and likely originated and remained in coexistence with a clade of salamander hosts for millions of years in Asia.

TL;DR: Aquaporin-4 contains a short 3(10) helix in an extracellular loop, which mediates weak but specific interactions between AQP4 molecules in adjoining membranes, which suggests a previously unexpected role for AQP 4 in cell adhesion.

TL;DR: The structure of mammalian claudin-19 in complex with C-CPE at 3.7 Å resolution shows that C- CPE forms extensive hydrophobic and hydrophilic interactions with the two extracellular segments of claud in-19, and shows that helix displacement may underlie C-CCPE–mediated disassembly of TJs.

TL;DR: The structure of AQP4, the predominant water channel in the brain, reveals eight water molecules in the channel and visualizes five lipids, showing that direct interactions of the extracellular surface of AQp4 with three lipids in the adjoining membrane help stabilize the membrane junction.