K
Krishnadev Oruganty
Researcher at University of Georgia
Publications - 15
Citations - 750
Krishnadev Oruganty is an academic researcher from University of Georgia. The author has contributed to research in topics: Protein structure & Protein kinase domain. The author has an hindex of 11, co-authored 15 publications receiving 620 citations. Previous affiliations of Krishnadev Oruganty include University of Michigan.
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Journal ArticleDOI
Deciphering the structural basis of eukaryotic protein kinase regulation.
Hiruy S. Meharena,Philip Chang,Malik M. Keshwani,Krishnadev Oruganty,Aishwarya Nene,Natarajan Kannan,Susan S. Taylor,Alexandr P. Kornev +7 more
TL;DR: Biochemical and structural analysis of two features of kinase structure, the “R-spine” and “Shell,” afford a detailed insight into the regulation of eukaryotic protein kinases.
Journal ArticleDOI
The entropic force generated by intrinsically disordered segments tunes protein function
Nicholas D. Keul,Krishnadev Oruganty,Schaper Bergman Et,Nathaniel R. Beattie,Weston E. McDonald,Renuka Kadirvelraj,Michael L. Gross,Robert S. Phillips,Stephen C. Harvey,Zachary A. Wood +9 more
TL;DR: It is shown that the entropic force produced by an intrinsically disordered carboxy terminus (ID-tail) shifts the conformational ensemble of human UDP-α-d-glucose-6-dehydrogenase (UGDH) towards a substate with a high affinity for an allosteric inhibitor.
Journal ArticleDOI
Mitochondrial ADCK3 Employs an Atypical Protein Kinase-like Fold to Enable Coenzyme Q Biosynthesis
Jonathan A. Stefely,Andrew G. Reidenbach,Arne Ulbrich,Krishnadev Oruganty,Brendan J. Floyd,Adam Jochem,Jaclyn M. Saunders,Isabel E. Johnson,Catherine E. Minogue,Russell L. Wrobel,Grant E. Barber,David Lee,Sheng Li,Natarajan Kannan,Joshua J. Coon,Craig A. Bingman,David J. Pagliarini +16 more
TL;DR: It is found that multiple UbiB-specific features are poised to inhibit protein kinase activity, including an N-terminal domain that occupies the typical substrate binding pocket and a unique A-rich loop that limits ATP binding by establishing an unusual selectivity for ADP.
Proceedings ArticleDOI
Relation extraction from clinical texts using domain invariant convolutional neural network
TL;DR: The results indicate that convolution neural network can be a good model for relation exaction in clinical text without being dependent on expert's knowledge on defining quality features.
Journal ArticleDOI
The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner.
Fiona P. Bailey,Dominic P. Byrne,Krishnadev Oruganty,Claire E. Eyers,Christopher Novotny,Kevan M. Shokat,Natarajan Kannan,Patrick A. Eyers +7 more
TL;DR: It is reported that the human pseudokinase TRB2 retains the ability to both bind and hydrolyse ATP weakly in vitro and it is established that the nucleotide-binding site of an 'analogue-sensitive'TRB2 mutant can be targeted with specific bulky ligands of the pyrazolo-pyrimidine (PP) chemotype.