K
Kristin D. Schleicher
Researcher at Massachusetts Institute of Technology
Publications - 12
Citations - 637
Kristin D. Schleicher is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Catalysis & Coupling reaction. The author has an hindex of 7, co-authored 12 publications receiving 610 citations. Previous affiliations of Kristin D. Schleicher include Scripps Research Institute & IBM.
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Journal ArticleDOI
Structurally diverse dendritic libraries : A highly efficient functionalization approach using Click chemistry
Michael Malkoch,Michael Malkoch,Kristin D. Schleicher,Eric Drockenmuller,Eric Drockenmuller,Craig J. Hawker,Craig J. Hawker,Thomas P. Russell,Peng Wu,Valery V. Fokin +9 more
TL;DR: The high fidelity and efficiency of Click chemistry are exploited in the synthesis of a library of chain end functionalized dendritic macromolecules, demonstrating an evolving synergy between advanced organic chemistry and functional materials.
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A Remarkable Series of Vinblastine Analogues Displaying Enhanced Activity and an Unprecedented Tubulin Binding Steric Tolerance: C20' Urea Derivatives
TL;DR: Key structural features of the urea-based analogues that contribute to their properties and provided derivatives that match or exceed the potency of vinblastine by as much as 10-fold in cell-based functional assays are defined.
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Nickel-catalyzed synthesis of acrylamides from alpha-olefins and isocyanates.
TL;DR: The nickel(0)-catalyzed coupling of alpha-olefins and isocyanates proceeds in the presence of the N-heterocyclic carbene ligand IPr to provide alpha,beta-unsaturated amides.
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Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign.
Kristin D. Schleicher,Yoshikazu Sasaki,Annie Tam,Daisuke Kato,Katharine K. Duncan,Dale L. Boger +5 more
TL;DR: Two potent analogues possessing two different unprecedented modifications to the vindoline subunit core architecture were discovered that matched the potency of the comparison natural products and both lack the 6,7-double bond whose removal in vinblastine leads to a 100-fold drop in activity.
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Nickel-catalyzed coupling reactions of alkenes
TL;DR: Several reactions of simple, unactivated alkenes with electrophiles under Ni(0) catalysis are discussed, which act as the functional equivalents of alkenyl- and allylmetal reagents in these methods.