Kristine Grindle

TL;DR: The nasopharynx is a reservoir for microbes associated with acute respiratory infections (ARIs) and targeting pathogenic bacteria within the NP microbiome could represent a prophylactic approach to asthma.

TL;DR: Adding omalizumab before return to school to ongoing guidelines-based care among inner-city youth reduces fall asthma exacerbations, particularly among those with a recent exacerbation.

TL;DR: Results indicate that airway IL-8 and G-CSF are closely associated with virus-induced neutrophilic inflammation during an experimental RV infection in atopic volunteers, and the balance of airway T-helper cell type 1 (Th1)- and Th2-like cytokines induced by RV infection may help determine the clinical outcome of common cold infections.

TL;DR: It is demonstrated that repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in children, and monitoring NPM composition may enable early detection and intervention in high-risk children.

TL;DR: DSRNA selectively induce the secretion of chemokines such as IL-8 and RANTES, and implicate dsRNA-sensitive signaling proteins in this process, suggesting that this may be an important mechanism for the selective secretion of Chemokines by viruses that synthesize ds RNA during replication.