K
Kym Pham
Researcher at University of Melbourne
Publications - 12
Citations - 1094
Kym Pham is an academic researcher from University of Melbourne. The author has contributed to research in topics: Microbiome & Deep sequencing. The author has an hindex of 8, co-authored 12 publications receiving 836 citations. Previous affiliations of Kym Pham include Hudson Institute of Medical Research & Monash University, Clayton campus.
Papers
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Journal ArticleDOI
The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development
Shu Mei Teo,Danny Mok,Kym Pham,Merci Kusel,Michael Serralha,Niamh M. Troy,Barbara J. Holt,Belinda J. Hales,Michael L. Walker,Elysia M. Hollams,Yury A. Bochkov,Kristine Grindle,Sebastian L. Johnston,James E. Gern,Peter D. Sly,Patrick G. Holt,Kathryn E. Holt,Michael Inouye +17 more
TL;DR: The nasopharynx is a reservoir for microbes associated with acute respiratory infections (ARIs) and targeting pathogenic bacteria within the NP microbiome could represent a prophylactic approach to asthma.
Journal ArticleDOI
Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture
Fanny Grillet,Elsa Bayet,Elsa Bayet,Elsa Bayet,Olivia Villeronce,Olivia Villeronce,Olivia Villeronce,Luke Zappia,Ebba Louise Lagerqvist,Ebba Louise Lagerqvist,Ebba Louise Lagerqvist,Sebastian Lunke,Emmanuelle Charafe-Jauffret,Kym Pham,Christina Mølck,Nathalie Rolland,Jean-François Bourgaux,Michel Prudhomme,Claire Philippe,Sophie Bravo,Jean Christophe Boyer,Lucile Canterel-Thouennon,Graham R. Taylor,Arthur Hsu,Jean-Marc Pascussi,Jean-Marc Pascussi,Jean-Marc Pascussi,Frédéric Hollande,Julie Pannequin,Julie Pannequin,Julie Pannequin +30 more
TL;DR: The existence of patient-derived colorectal CTCs that bear all the functional attributes of CSCs are directly demonstrated, and RNA sequencing analyses strikingly demonstrate that drug metabolising pathways represent the most upregulated feature among CTC lines in comparison with primary CRC cells grown under similar conditions.
Journal ArticleDOI
Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease.
Shu Mei Teo,Shu Mei Teo,Shu Mei Teo,Howard H.F. Tang,Howard H.F. Tang,Howard H.F. Tang,Danny Mok,Louise M. Judd,Stephen C. Watts,Kym Pham,Barbara J. Holt,Merci M.H. Kusel,Michael Serralha,Niamh M. Troy,Yury A. Bochkov,Kristine Grindle,Robert F. Lemanske,Sebastian L. Johnston,James E. Gern,Peter D. Sly,Patrick G. Holt,Patrick G. Holt,Kathryn E. Holt,Kathryn E. Holt,Kathryn E. Holt,Michael Inouye +25 more
TL;DR: It is demonstrated that repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in children, and monitoring NPM composition may enable early detection and intervention in high-risk children.
Journal ArticleDOI
A mutant BRAF V600E-specific immunohistochemical assay: correlation with molecular mutation status and clinical outcome in colorectal cancer
Fiona Day,Andrea Muranyi,Shalini Singh,Kandavel Shanmugam,David S. Williams,David J Byrne,Kym Pham,Michelle Palmieri,Michelle Palmieri,Jeanne Tie,Thomas M. Grogan,Peter Gibbs,Oliver M. Sieber,Oliver M. Sieber,Paul Waring,Jayesh Desai +15 more
TL;DR: The accuracy and clinical utility of a recently developed BRAF V600E IHC method as a prognostic biomarker in a large cohort of community-based CRC patients was evaluated and it was found that BRAF mutation status was correlated with overall survival (OS) in stage IV CRC.
Journal ArticleDOI
Evaluating the Genomic Yield of a Single Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in Lung Cancer: Meeting the Challenge of Doing More With Less.
Tracy L. Leong,Tracy L. Leong,Michael Christie,Sevastjan Kranz,Kym Pham,Arthur Hsu,Louis Irving,Marie Liesse Asselin-Labat,Daniel P Steinfort,Daniel P Steinfort +9 more
TL;DR: It is shown that a single endobronchial ultrasound‐guided needle aspiration yields sufficient DNA to support genetic analysis with high diagnostic accuracy for clinically important mutations, which has significant implications for procedural performance in lung cancer cases where genetic alterations are highly suspected.