Kristoffer Famm

TL;DR: Kristoffer Famm and colleagues unveil a multidisciplinary initiative to develop medicines that use electrical impulses to modulate the body's neural circuits.

TL;DR: The method should be useful for making aggregation-resistant proteins and for helping to identify features that promote or prevent protein aggregation, including those responsible for misfolding diseases.

TL;DR: An interdisciplinary community puts forward a research roadmap for the next 5 years that aims to realize the vision of a new class of medicines based on modulating the electrical signalling patterns of the peripheral nervous system.

TL;DR: The selection process yielded domains that combined thermodynamic stability and aggregation-resistant unfolded states that were resistant to acid aggregation, and it is suggested that changes to these properties are controlled by the extent to which the folding equilibrium is displaced during the process of selection.

TL;DR: In this paper, the authors introduce the notion of a library of polypeptides that unfold reversibly (e.g., unfolds when heated and refolds when cooled), which is similar to the library of nucleic acids that can be used to encode polypeptic sequences.