W
William C. Comb
Researcher at Massachusetts Institute of Technology
Publications - 11
Citations - 1861
William C. Comb is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: GTPase & mTORC1. The author has an hindex of 7, co-authored 9 publications receiving 1443 citations.
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Nutrient-sensing mechanisms and pathways
TL;DR: The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life as mentioned in this paper, which is a selective pressure that has shaped the evolution of most cellular processes, such as the mobilization of internal stores through autophagy.
Journal ArticleDOI
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
Shuyu Wang,Zhi-Yang Tsun,Rachel L. Wolfson,Kuang Shen,Gregory A. Wyant,Molly Plovanich,Elizabeth D. Yuan,Tony D. Jones,Lynne Chantranupong,William C. Comb,Timothy C. Wang,Liron Bar-Peled,Roberto Zoncu,Christoph Straub,Choah Kim,Jiwon Park,Bernardo L. Sabatini,David M. Sabatini +17 more
TL;DR: SLC38A9, an uncharacterized protein with sequence similarity to amino acid transporters, is identified as a lysosomal transmembrane protein that interacts with the Rag guanosine triphosphatases and Ragulator in an amino acid–sensitive fashion and is an excellent candidate for being an arginine sensor for the mTORC1 pathway.
Journal ArticleDOI
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.
Yoav D. Shaul,Elizaveta Freinkman,William C. Comb,Jason R. Cantor,Wai Leong Tam,Wai Leong Tam,Prathapan Thiru,Dohoon Kim,Naama Kanarek,Michael E. Pacold,Michael E. Pacold,Walter W. Chen,Brian Bierie,Richard Possemato,Ferenc Reinhardt,Robert A. Weinberg,Michael B. Yaffe,David M. Sabatini +17 more
TL;DR: This work identified metabolic processes essential for the EMT, a program associated with the acquisition of metastatic and aggressive cancer cell traits, through its catalytic activity and enzymatic products, the dihydropyrimidines.
Nutrient-sensing mechanisms and pathways
TL;DR: This work states that during food abundance, nutrient-sensing pathways engage anabolism and storage, whereas scarcity triggers homeostatic mechanisms, such as the mobilization of internal stores through autophagy.