Molly Plovanich

TL;DR: Genome phylogenetic profiling, genome-wide RNA co-expression analysis and organelle-wide protein coexpression analysis are used to predict proteins functionally related to MICU1, establishing MCU as an essential component of the mitochondrial Ca2+ uniporter.

TL;DR: SLC38A9, an uncharacterized protein with sequence similarity to amino acid transporters, is identified as a lysosomal transmembrane protein that interacts with the Rag guanosine triphosphatases and Ragulator in an amino acid–sensitive fashion and is an excellent candidate for being an arginine sensor for the mTORC1 pathway.

TL;DR: The results identify MICU2 as a new component of the uniporter complex that may contribute to the tissue-specific regulation of this channel, and provide multiple lines of biochemical evidence that MCU, MICU1 andMICU2 reside within a complex and cross-stabilize each other's protein expression in a cell-type dependent manner.

TL;DR: Yeast is used as a facile reconstitution system to identify the minimal components sufficient for in vivo uniporter activity and confirms that MCU is the pore-forming subunit, defines the minimal genetic elements sufficient for metazoan and nonmetazoan uniporters activity, and provides valuable insight into the evolution of the unipporter machinery.

TL;DR: Black and Latinx patients were less likely to be admitted to cardiology for HF care, and admission to the cardiology service was independently associated with decreased readmission within 30 days, independent of race.