K
Kunisuke Izawa
Researcher at Ajinomoto
Publications - 139
Citations - 3842
Kunisuke Izawa is an academic researcher from Ajinomoto. The author has contributed to research in topics: Amino acid & Yield (chemistry). The author has an hindex of 21, co-authored 139 publications receiving 2984 citations. Previous affiliations of Kunisuke Izawa include Rega Institute for Medical Research.
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Journal ArticleDOI
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
Yu Zhou,Jiang Wang,Zhanni Gu,Shuni Wang,Wei Zhu,José Luis Aceña,Vadim A. Soloshonok,Kunisuke Izawa,Hong Liu +8 more
TL;DR: Compounds Currently in Phase II−III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas is presented.
Journal ArticleDOI
Recent advances in the trifluoromethylation methodology and new CF3-containing drugs
Wei Zhu,Jiang Wang,Shuni Wang,Zhanni Gu,José Luis Aceña,Kunisuke Izawa,Hong Liu,Vadim A. Soloshonok,Vadim A. Soloshonok +8 more
TL;DR: A brief assessment of the methodological field of trifluoromethylation and its possible impact on the development of new CF 3 -containing pharmaceuticals is provided in this paper.
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Palladium-catalyzed double carbonylation of aryl halides to give .alpha.-keto amides. Mechanistic studies
Fumiyuki Ozawa,Hidehiko Soyama,Hisayoshi Yanagihara,Issei Aoyama,Hiroaki Takino,Kunisuke Izawa,Takakazu Yamamoto,Akio Yamamoto +7 more
TL;DR: Divers halogenures d'aryles sont convertis catalytiquement en α-cetoamides and amides par traitement avec des amines secondaires and le monoxyde de carbone.
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Next generation organofluorine containing blockbuster drugs
Jianlin Han,Attila Márió Remete,Luca S. Dobson,Loránd Kiss,Kunisuke Izawa,Hiroki Moriwaki,Vadim A. Soloshonok,Vadim A. Soloshonok,David O'Hagan +8 more
TL;DR: This Review highlights a selection of the most successful organo-fluorine drugs, that have achieved blockbuster status, namely, sitagliptin (diabetes), sofosbuvir (hepatitis C), emtricitabine (HIV), glecaprevir/pibrentasvir ( hepatitisC), elvitegravir (Hiv), dolutegravirs (H HIV), bictegravIR (H IV),
Journal ArticleDOI
Applications of fluorine-containing amino acids for drug design.
Haibo Mei,Jianlin Han,Karel D. Klika,Kunisuke Izawa,Tatsunori Sato,Nicholas A. Meanwell,Vadim A. Soloshonok,Vadim A. Soloshonok +7 more
TL;DR: The goal of this Review article is to highlight the current state-of-the-art in this area by profiling 42 selected compounds that combine fluorine and amino acid structural elements, including examples of drug-candidates that although withdrawn from development had a significant impact on the progress of medicinal chemistry and/or provided a deeper understanding of the nature and mechanism of biological action.