K
Kyounghyun Kim
Researcher at University of Cincinnati
Publications - 42
Citations - 5737
Kyounghyun Kim is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Transcription factor & Estrogen receptor. The author has an hindex of 28, co-authored 42 publications receiving 5323 citations. Previous affiliations of Kyounghyun Kim include Texas A&M University System & Hospital Corporation of America.
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Journal ArticleDOI
Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
Willscott E. Naugler,Toshiharu Sakurai,Sunhwa Kim,Shin Maeda,Kyounghyun Kim,Ahmed M. Elsharkawy,Ahmed M. Elsharkawy,Michael Karin +7 more
TL;DR: It is proposed that estrogen-mediated inhibition of IL-6 production by KCs reduces liver cancer risk in females, and these findings may be used to prevent HCC in males.
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Hotair is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer
Kyounghyun Kim,Indira Jutooru,Gayathri Chadalapaka,Greg A. Johnson,James H. Frank,Robert C. Burghardt,Sang Bae Kim,Stephen Safe,Stephen Safe +8 more
TL;DR: HOTAIR expression is increased in pancreatic tumors compared with non-tumor tissue and is associated with more aggressive tumors, and HOTAIR uniquely suppressed several interferon-related genes and gene sets related to cell cycle progression in Pancic cancer cells and tumors.
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Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols.
TL;DR: Tea polyphenol-induced production of H2O2 may mediate apoptosis and that this may contribute to the growth inhibitory activities of tea polyphenols in vitro.
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Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways
Stephen Safe,Kyounghyun Kim +1 more
TL;DR: This review summarizes some of the characteristics of ER/Sp- and ER/AP-1-mediated transactivation, which are dependent on ligand structure, cell context, ER-subtype (ERalpha and ERbeta), and Sp protein and demonstrates that this non-classical genomic pathway is also functional in vivo.
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Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer.
Kyounghyun Kim,Gayathri Chadalapaka,Syng Ook Lee,Daisuke Yamada,Xavier Sastre-Garau,Pierre-Antoine Defossez,Yun-Yong Park,Ju Seog Lee,Stephen Safe,Stephen Safe +9 more
TL;DR: The experimental results confirm that ZBTB4 functions as a novel tumor-suppressor gene with prognostic significance for breast cancer survival, and the oncogenic miR-17-92/ZBTB 4/Sp axis may be a potential therapeutic target.