L. Bilet

TL;DR: It is demonstrated that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.

TL;DR: This study is the first to demonstrate that NAD+ boosters can also directly affect skeletal muscle mitochondrial function in humans and shows that acipimox treatment resulted in a robust elevation in expression of nuclear-encoded mitochondrial gene sets and a mitonuclear protein imbalance, which may indicate activation of the mitochondrial unfolded protein response.

TL;DR: In this article, the authors examined to what extent physical activity contributes to the decline in mitochondrial function and muscle health during aging and compared mitochondrial function in young and older adults, with similar habitual physical activity levels.

TL;DR: Elevated plasma FA concentrations, induced by exercise in the fasted state, lead to increased cardiac lipid content, but do not acutely hamper systolic function.

TL;DR: Whether PPAR agonist treatment in patients and carriers of a PNPLA2 gene defect could also have beneficial effects is investigated, suggesting that lipolysis-derived fatty acids or fatty acid byproducts serve as transcriptional activators of PPARs.