S
Silvie Timmers
Researcher at Wageningen University and Research Centre
Publications - 44
Citations - 2801
Silvie Timmers is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Resveratrol & Skeletal muscle. The author has an hindex of 20, co-authored 36 publications receiving 2434 citations. Previous affiliations of Silvie Timmers include Maastricht University Medical Centre & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
Silvie Timmers,Ellen Konings,L. Bilet,Riekelt H. Houtkooper,Tineke van de Weijer,Gijs H. Goossens,Joris Hoeks,Sophie E. van der Krieken,Dongryeol Ryu,Sander Kersten,Esther Moonen-Kornips,Matthijs K. C. Hesselink,Iris Kunz,Vera B. Schrauwen-Hinderling,Ellen E. Blaak,Johan Auwerx,Patrick Schrauwen +16 more
TL;DR: It is demonstrated that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.
Journal ArticleDOI
Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle
Eija Pirinen,Eija Pirinen,Eija Pirinen,Carles Cantó,Young Suk Jo,Laia Morató,Hongbo Zhang,Keir J. Menzies,Evan G. Williams,Laurent Mouchiroud,Norman Moullan,Carolina E. Hagberg,Carolina E. Hagberg,Wei Li,Silvie Timmers,Silvie Timmers,Ralph Imhof,Jef Verbeek,Jef Verbeek,Aurora Pujol,Barbara van Loon,Carlo Viscomi,Massimo Zeviani,Patrick Schrauwen,Anthony A. Sauve,Kristina Schoonjans,Johan Auwerx +26 more
TL;DR: Tight negative correlation between Parp-1 expression and energy expenditure in heterogeneous mouse populations is shown, indicating that variations in PARP-1 activity have an impact on metabolic homeostasis and can be translated into pharmacological applications.
Journal ArticleDOI
The journey of resveratrol from yeast to human
TL;DR: The natural polyphenolic compound resveratrol was first discovered in the 1940s and received renewed interest as several findings implicated this compound as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms.
Journal ArticleDOI
Muscular diacylglycerol metabolism and insulin resistance.
TL;DR: The evidence that implicates DAG being central in the development of muscular insulin resistance is discussed and if and how modulation of skeletal muscle DAG levels could function as a possible therapeutic target for the treatment of type 2 diabetes mellitus is discussed.
Journal ArticleDOI
Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels
Madeleen Bosma,Matthijs K. C. Hesselink,Lauren M. Sparks,Silvie Timmers,Maria J. Ferraz,Frits Mattijssen,Denis van Beurden,Gert Schaart,Marc H. De Baets,Fons Verheyen,Sander Kersten,Patrick Schrauwen +11 more
TL;DR: It is concluded that PLIN2 is essential for lipid storage in skeletal muscle by enhancing the partitioning of excess FAs toward TAG storage in LDs, thereby blunting lipotoxicity-associated insulin resistance.