L
L. Jaap Kappelle
Researcher at University Medical Center Utrecht
Publications - 40
Citations - 3018
L. Jaap Kappelle is an academic researcher from University Medical Center Utrecht. The author has contributed to research in topics: Stroke & Modified Rankin Scale. The author has an hindex of 19, co-authored 40 publications receiving 2437 citations. Previous affiliations of L. Jaap Kappelle include University Medical Center & Erasmus University Rotterdam.
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Journal ArticleDOI
Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial
Jeannette Hofmeijer,L. Jaap Kappelle,Ale Algra,G Johan Amelink,Jan van Gijn,H. Bart van der Worp +5 more
TL;DR: Surgical decompression reduces case fatality and poor outcome in patients with space-occupying infarctions who are treated within 48 h of stroke onset and there is no evidence that this operation improves functional outcome when it is delayed for up to 96 h after stroke onset.
Journal ArticleDOI
Intraoperative hypotension and perioperative ischemic stroke after general surgery: a nested case-control study
Jilles B. Bijker,Suzanne Persoon,Linda M. Peelen,Karel G. M. Moons,Cor J. Kalkman,L. Jaap Kappelle,Wilton A. van Klei +6 more
TL;DR: Intraoperative hypotension might play a role in the development of postoperative ischemic stroke, and especially for mean blood pressure values decreasing more than 30% from baseline blood pressure, an association with postoperativeIsChemic stroke risks was observed.
Journal ArticleDOI
Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection
Stéphanie Debette,Stéphanie Debette,Annette Compter,M.-A. Labeyrie,Maarten Uyttenboogaart,T. M. Metso,Jennifer J. Majersik,Barbara Goeggel-Simonetti,Stefan T. Engelter,Alessandro Pezzini,Philippe Bijlenga,Andrew M. Southerland,Olivier Naggara,Yannick Béjot,John W. Cole,Anne Ducros,Giacomo Giacalone,Sabrina Schilling,Peggy Reiner,Hakan Sarikaya,Janna C Welleweerd,L. Jaap Kappelle,Gert J. de Borst,Leo H. Bonati,Simon Jung,Vincent Thijs,Juan Jose Martin,Tobias Brandt,Caspar Grond-Ginsbach,Manja Kloss,Tohru Mizutani,Kazuo Minematsu,James F. Meschia,Vitor Mendes Pereira,Anna Bersano,Emmanuel Touzé,Philippe Lyrer,Didier Leys,Hugues Chabriat,Hugh S. Markus,Bradford B. Worrall,Stéphane Chabrier,R W Baumgartner,Christian Stapf,Turgut Tatlisumak,Marcel Arnold,Marie-Germaine Bousser +46 more
TL;DR: Most patients with subarachnoid haemorrhage undergo surgical or endovascular treatment to prevent rebleeding, whereas patients with intracranial artery dissection and cerebral ischaemia are treated with antithrombotics.
Journal ArticleDOI
Cognitive function in patients with diabetes mellitus: guidance for daily care.
Paula S. Koekkoek,L. Jaap Kappelle,Esther van den Berg,Esther van den Berg,Guy E.H.M. Rutten,Geert Jan Biessels +5 more
TL;DR: Although cognitive decrements do not generally represent a pre-dementia stage in patients below the age of 60-65 years, in older individuals these subtle cognitive changes might represent the earliest stages of a dementia process.
Journal ArticleDOI
The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial
Heleen M. den Hertog,H. Bart van der Worp,H. Maarten A. van Gemert,Ate Algra,L. Jaap Kappelle,Jan van Gijn,Peter J. Koudstaal,Diederik W.J. Dippel +7 more
TL;DR: These results do not support routine use of high-dose paracetamol in patients with acute stroke and might have a beneficial effect on functional outcome in patients admitted with a body temperature 37-39 degrees C, but this post-hoc finding needs further study.