K
Knut Kotarsky
Researcher at Lund University
Publications - 38
Citations - 2718
Knut Kotarsky is an academic researcher from Lund University. The author has contributed to research in topics: Receptor & Reporter gene. The author has an hindex of 18, co-authored 34 publications receiving 2450 citations. Previous affiliations of Knut Kotarsky include Tokyo Institute of Technology.
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Journal ArticleDOI
IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation.
Emma Persson,Heli Uronen-Hansson,Monika Semmrich,Aymeric Rivollier,Karin Hägerbrand,Jan Marsal,Sigurdur Gudjonsson,Ulf Håkansson,Boris Reizis,Knut Kotarsky,William W. Agace,William W. Agace +11 more
TL;DR: It is demonstrated that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4), and results suggest a central role for IRF4-dependent, IL-6 producing CD103 (+) CD11b (+) DCs in intestinal Th17 cell differentiation.
Journal ArticleDOI
Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
TL;DR: The human gene to be predominantly expressed in peripheral blood leukocytes and, to a lesser extent, in spleen is found, and the designation FFA(2)R is suggested to be given to this second receptor activated by free fatty acids.
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A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs.
TL;DR: A human cell surface receptor that is specifically activated by medium to long-chain free fatty acids is reported, which belongs to the class of seven-transmembrane, G-protein coupled receptors (GPCRs) and also mediates responses to antidiabetic drugs of the thiazolidinedione type.
Journal ArticleDOI
Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes
Knut Kotarsky,Åke Boketoft,Jesper Bristulf,Niclas E. Nilsson,Åke Norberg,Stefan R. Hansson,Christer Owman,Rannar Sillard,L. M. Fredrik Leeb-Lundberg,Björn Olde +9 more
TL;DR: The ligand binding, activation, and tissue distribution of the orphan G protein-coupled receptor (GPCR) GPR92 were studied and it was found that it is the most abundant GPCR activated by LPA found in the small intestinal intraepithelial CD8+ cytotoxic T cells.
Journal ArticleDOI
CCR2(+)CD103(-) intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells.
Charlotte L. Scott,Calum C. Bain,Pamela B. Wright,Dorine Sichien,Knut Kotarsky,Emma Persson,Katarzyna Müller Luda,Martin Guilliams,Bart N. Lambrecht,William W. Agace,S Wf Milling,Allan McI. Mowat +11 more
TL;DR: It is shown that intestinal CD103−CD11b+ MPs can be separated clearly into DCs and mφs based on phenotype, gene profile, and kinetics, and a bona fide population of CCR2+ DCs that is involved in priming mucosal T helper type 17 (Th17) responses is revealed.