H
H. van der Klift
Researcher at Leiden University
Publications - 14
Citations - 1444
H. van der Klift is an academic researcher from Leiden University. The author has contributed to research in topics: Adenomatous polyposis coli & Familial adenomatous polyposis. The author has an hindex of 12, co-authored 14 publications receiving 1426 citations.
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Journal ArticleDOI
Familial endometrial cancer in female carriers of MSH6 germline mutations
Juul T. Wijnen,W. J. F. De Leeuw,Hans F. A. Vasen,H. van der Klift,Pål Møller,Astrid Stormorken,Hanne Meijers-Heijboer,Dick Lindhout,Fred H. Menko,S Vossen,G Moslein,Carli M. J. Tops,A Brocker-Vriends,Ying Wu,Robert M. W. Hofstra,Rolf H. Sijmons,Cees J. Cornelisse,Hans Morreau,Riccardo Fodde +18 more
TL;DR: Hereditary non-polyposis colorectal cancer was shown to be caused by germline mutations in the DNA mismatch repair genes MSH2, MLH1, PMS1,PMS2 and MSH6, and many HNPCC families do not fully comply with the clinical Amsterdam criteria, and the causative mutations are unknown.
Journal ArticleDOI
Clinical findings with implications for genetic testing in families with clustering of colorectal cancer.
Juul T. Wijnen,H. F. A. Vasen,P M Khan,Aeilko H. Zwinderman,H. van der Klift,Adri Mulder,C. Tops,Pål Møller,Riccardo Fodde,Fred H. Menko,B. G. Taal,Fokko N. Nagengast,Han G. Brunner,Jan H. Kleibeuker,Rolf H. Sijmons,Gerrit Griffioen,Ahjt Brocker-Vriends,Egbert Bakker,van Leeuwen-Cornelisse,A Meijers-Heijboer,Dick Lindhout,Martijn H. Breuning,J.G. Post,C Schaap,Jaran Apold,Ketil Heimdal,Lucio Bertario,Marie Luise Bisgaard,P. Goetz +28 more
TL;DR: Assessment of clinical findings can improve the rate of detection of mutations of DNA mismatch-repair genes in families suspected of having hereditary nonpolyposis colorectal cancer.
Journal ArticleDOI
Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP)
Maartje Nielsen,Patrick Franken,T H C M Reinards,Marjan M. Weiss,A Wagner,H. van der Klift,S. Kloosterman,Jeanine J. Houwing-Duistermaat,Cora M. Aalfs,M. G. E. M. Ausems,A H J T Bröcker-Vriends,E. B. Gomez Garcia,Nicoline Hoogerbrugge,Fred H. Menko,Rolf H. Sijmons,S. Verhoef,Ernst J. Kuipers,Hans Morreau,Martijn H. Breuning,C. Tops,Juul T. Wijnen,Hans F. A. Vasen,Riccardo Fodde,Frederik J. Hes +23 more
TL;DR: Polyp numbers in MAP patients were equally associated with the attenuated and classical polyposis coli phenotypes, and two thirds of the MAP patients had colorectal cancer, 95% of whom were older than 35 years, and one third of a subset of patients had upper gastrointestinal lesions.
Journal Article
Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16
Juul T. Wijnen,P M Khan,Hans F. A. Vasen,Fred H. Menko,H. van der Klift,M. van den Broek,I. S. J. van Leeuwen-Cornelisse,Fokko N. Nagengast,E. J. Meijers-Heijboer,Dick Lindhout,Gerrit Griffioen,A. Cats,Jan H. Kleibeuker,L. Varesco,Lucio Bertario,Marie Luise Bisgaard,J. Mohr,Richard D. Kolodner,Riccardo Fodde +18 more
TL;DR: While the spectrum of mutations at the hMSH2 gene among HNPCC patients appears heterogeneous, a cluster of hMLH1 mutations has been found in the region encompassing exons 15 and 16, which accounts for 50% of all the independent hMLh1 mutations described to date and for > 20% of the unrelated HNP CC kindreds here analyzed.
Journal ArticleDOI
Presymptomatic diagnosis of familial adenomatous polyposis by bridging DNA markers.
C. Tops,Gerrit Griffioen,Hans F. A. Vasen,Cor Breukel,H. van der Klift,J. Th. Wijnen,Inge van Leeuwen,F. C. A. den Hartog Jager,Fokko M. Nagengast,Cornelis B.H.W. Lamers,P. Meera Khan +10 more
TL;DR: An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side, which will allow prenatal and presymptomatic diagnosis of FAP.