F
Fokko N. Nagengast
Researcher at Radboud University Nijmegen
Publications - 5
Citations - 1042
Fokko N. Nagengast is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Gene mutation & Colorectal cancer. The author has an hindex of 3, co-authored 5 publications receiving 1015 citations.
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Journal ArticleDOI
Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)
Hans F. A. Vasen,G Moslein,Angel Alonso,Inge Bernstein,Lucio Bertario,Ignacio Blanco,John Burn,Gabriel Capellá,Christoph Engel,Ian M. Frayling,Waltraut Friedl,Frederik J. Hes,Shirley Hodgson,Jukka-Pekka Mecklin,Pål Møller,Fokko N. Nagengast,Yann Parc,Laura Renkonen-Sinisalo,Julian R. Sampson,Astrid Stormorken,Juul T. Wijnen +20 more
TL;DR: In this article, the authors present guidelines for the clinical management of families with Lynch syndrome based on a systematic literature search using Pubmed and the Cochrane Database of Systematic Reviews reference lists of retrieved articles.
Journal ArticleDOI
Clinical findings with implications for genetic testing in families with clustering of colorectal cancer.
Juul T. Wijnen,H. F. A. Vasen,P M Khan,Aeilko H. Zwinderman,H. van der Klift,Adri Mulder,C. Tops,Pål Møller,Riccardo Fodde,Fred H. Menko,B. G. Taal,Fokko N. Nagengast,Han G. Brunner,Jan H. Kleibeuker,Rolf H. Sijmons,Gerrit Griffioen,Ahjt Brocker-Vriends,Egbert Bakker,van Leeuwen-Cornelisse,A Meijers-Heijboer,Dick Lindhout,Martijn H. Breuning,J.G. Post,C Schaap,Jaran Apold,Ketil Heimdal,Lucio Bertario,Marie Luise Bisgaard,P. Goetz +28 more
TL;DR: Assessment of clinical findings can improve the rate of detection of mutations of DNA mismatch-repair genes in families suspected of having hereditary nonpolyposis colorectal cancer.
Journal Article
Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16
Juul T. Wijnen,P M Khan,Hans F. A. Vasen,Fred H. Menko,H. van der Klift,M. van den Broek,I. S. J. van Leeuwen-Cornelisse,Fokko N. Nagengast,E. J. Meijers-Heijboer,Dick Lindhout,Gerrit Griffioen,A. Cats,Jan H. Kleibeuker,L. Varesco,Lucio Bertario,Marie Luise Bisgaard,J. Mohr,Richard D. Kolodner,Riccardo Fodde +18 more
TL;DR: While the spectrum of mutations at the hMSH2 gene among HNPCC patients appears heterogeneous, a cluster of hMLH1 mutations has been found in the region encompassing exons 15 and 16, which accounts for 50% of all the independent hMLh1 mutations described to date and for > 20% of the unrelated HNP CC kindreds here analyzed.
Journal ArticleDOI
Colonoscopic screening of carriers of mismatch repair gene mutations: Results from the Dutch HNPCC registry.
Hans F. A. Vasen,Juul T. Wijnen,Fokko N. Nagengast,Gerrit Griffioen,Fred H. Menko,Babs G. Taal,Riccardo Fodde,Jan H. Kleibeuker +7 more
Journal ArticleDOI
An update of cancer risk in HNPCC: A study of 101 families including 58 families associated with mismatch repair mutations
Hans F. A. Vasen,Astrid Stormorken,Fokko N. Nagengast,Jan H. Kleibeuker,Gerrit Griffioen,Fred H. Menko,Riccardo Fodde,Babs G. Taal,Pål Møller,Juul T. Wijnen +9 more