N
Nikunj Sharma
Researcher at Case Western Reserve University
Publications - 13
Citations - 1980
Nikunj Sharma is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Proinflammatory cytokine & Inflammation. The author has an hindex of 11, co-authored 13 publications receiving 1751 citations. Previous affiliations of Nikunj Sharma include University of California, Santa Barbara & Cleveland State University.
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Journal ArticleDOI
Krüppel-like factor 4 regulates macrophage polarization
Xudong Liao,Nikunj Sharma,Fehmida Kapadia,Guangjin Zhou,Yuan Lu,Hong Hong,Kaavya Paruchuri,Ganapati H. Mahabeleshwar,Elise Dalmas,Nicolas Venteclef,Christopher A Flask,Julian A Kim,Bryan Doreian,Kurt Q. Lu,Klaus H. Kaestner,Anne Hamik,Karine Clément,Mukesh K. Jain +17 more
TL;DR: KLF4 was found to cooperate with Stat6 to induce an M2 genetic program and inhibit M1 targets via sequestration of coactivators required for NF-κB activation and mice bearing myeloid-specific deletion of KLF4 exhibited delayed wound healing and were predisposed to developing diet-induced obesity, glucose intolerance, and insulin resistance.
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Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease.
Seng Hui Low,Shivakumar Vasanth,Shivakumar Vasanth,Claire H. Larson,Sambuddho Mukherjee,Nikunj Sharma,Nikunj Sharma,Michael Kinter,Michelle E. Kane,Tomoko Obara,Thomas Weimbs +10 more
TL;DR: It is shown that PC1 undergoes proteolytic cleavage that results in nuclear translocation of its cytoplasmic tail and that this pathway is inappropriately activated in ADPKD.
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Circadian rhythms govern cardiac repolarization and arrhythmogenesis
Darwin Jeyaraj,Saptarsi M. Haldar,Xiaoping Wan,Mark McCauley,Juergen Ripperger,Kun Hu,Yuan Lu,Betty L. Eapen,Nikunj Sharma,Eckhard Ficker,Michael J. Cutler,James Gulick,Atsushi Sanbe,Jeffrey M. Robbins,Sophie Demolombe,Roman V. Kondratov,Steven Shea,Urs Albrecht,Xander H.T. Wehrens,David S. Rosenbaum,Mukesh K. Jain +20 more
TL;DR: Findings identify circadian transcription of ion channels as a mechanism for cardiac arrhythmogenesis through endogenous circadian rhythmicity under the control of a clock-dependent oscillator, krüppel-like factor 15 (Klf15).
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Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice
Guangjin Zhou,Anne Hamik,Lalitha Nayak,Hongmei Tian,Hong Shi,Yuan Lu,Nikunj Sharma,Xudong Liao,Andrew T. Hale,Lauren M Boerboom,Ryan E. Feaver,Huiyun Gao,Amar Desai,Alvin H. Schmaier,Stanton L. Gerson,Yunmei Wang,G. Brandon Atkins,Brett R. Blackman,Daniel I. Simon,Mukesh K. Jain +19 more
TL;DR: It is shown that endothelial KLF4 is an essential determinant of atherogenesis and thrombosis andMechanistically, it is demonstrated that KLF 4 differentially regulated pertinent endothelial targets via competition for the coactivator p300, and cogent evidence is provided implicated as essential in vivo regulators of vascular function in the adult animal.
Journal ArticleDOI
The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock
Ganapati H. Mahabeleshwar,Daiji Kawanami,Nikunj Sharma,Yoichi Takami,Guangjin Zhou,Hong Shi,Lalitha Nayak,Darwin Jeyaraj,Robert Grealy,Mary C. White,Ross McManus,Thomas J. Ryan,Patrick Leahy,Zhiyong Lin,Saptarsi M. Haldar,G. Brandon Atkins,Hector R. Wong,Jerry B. Lingrel,Mukesh K. Jain +18 more
TL;DR: In this paper, the authors identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo, and demonstrate that exposure to either hypoxia and/or bacterial products reduced KLF2 expression while inducing hypoxyia inducible factor 1α (HIF-1α), findings that were recapitulated in human septic patients.