LaRene Kuller

TL;DR: These studies demonstrate that sequential, phenotypic and antigenic variants represent viruses that have become increasingly fit for replication in the host and support the hypothesis that emerging variants have increased pathogenicity and drive disease progression in SIV and HIV infection.

TL;DR: The data suggest that African baboons may be resistant to infection by SIV/Mne, whereas Asian macaques are susceptible to infection with this pathogenic primate lentivirus.

TL;DR: Six newborn macaques rapidly developed neutralizing antibodies and had significantly reduced plasma viremia for six months, supporting the use ofneutralizing antibodies in enhancing B cell responses and viral control in perinatal settings.

TL;DR: It is clearly show that Tat can serve as an ADCC target, although the Tat-specific activity elicited did not correlate with better protection, and the higher ADCC and ADCVI activities seen in the Tat/Env group provide a plausible mechanism responsible for the greater chronic-phase protection.

TL;DR: The inability to productively infect macaques previously exposed to subinfectious doses of SIV suggests that a T-cell-mediated response may confer long-term protection against infection, and that AIDS vaccines should be designed to optimize the cellular arm of the immune response.