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Nancy L. Haigwood
Researcher at Oregon National Primate Research Center
Publications - 162
Citations - 9302
Nancy L. Haigwood is an academic researcher from Oregon National Primate Research Center. The author has contributed to research in topics: Antibody & Virus. The author has an hindex of 49, co-authored 158 publications receiving 8793 citations. Previous affiliations of Nancy L. Haigwood include University of North Carolina at Chapel Hill & Novartis.
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Journal ArticleDOI
Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis
Nirmal K. Banda,Jacques Bernier,David K. Kurahara,Roland Kurrle,Nancy L. Haigwood,Rafik P. Sekaly,Terri Helman Finkel +6 more
TL;DR: The data indicate that even picomolar concentrations of gp120 prime T cells for activation-induced cell death are found, suggesting a mechanism for CD4+ T cell depletion in acquired immune deficiency syndrome (AIDS), particularly in the face of concurrent infection and antigenic challenge with other organisms.
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Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys.
Riri Shibata,Tatsuhiko Igarashi,Nancy L. Haigwood,Alicia Buckler-White,Robert A. Ogert,William Ross,Ronald Willey,Michael W. Cho,Malcolm A. Martin +8 more
TL;DR: It is shown that anti–SHIV neutralizing activity, determined in vitro using an assay measuring loss of infectivity, is the absolute requirement for antibody–mediated protection in vivo.
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Tracking global patterns of N-linked glycosylation site variation in highly variable viral glycoproteins: HIV, SIV, and HCV envelopes and influenza hemagglutinin.
Ming Zhang,Brian Gaschen,Wendy M. Blay,Wendy M. Blay,Brian T. Foley,Nancy L. Haigwood,Nancy L. Haigwood,Carla Kuiken,Bette T. Korber +8 more
TL;DR: A new Web-based program developed to facilitate the sequon tracking and to define patterns allowed rapid visualization of the two distinctive patterns of sequon variation found in HIV-1, HIV-2, and SIV CPZ, and two shifting sites were identified.
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Effect of intron A from human cytomegalovirus (Towne) immediate-early gene on heterologous expression in mammalian cells
TL;DR: Evidence indicates that sequences in intron A positively regulate expression from the hCMV immediate-early enhancer/promoter in transformed monkey kidney cells.
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Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries
Carlos F. Barbas,Thomas A. Collet,Willi Amberg,Paul Roben,James M. Binley,Denise M. Hoekstra,Doug Cababa,Terri Jones,R. Anthony Williamson,Glenn R. Pilkington,Nancy L. Haigwood,Edelmira Cabezas,Arnold C. Satterthwait,Iñaki Sanz,Dennis R. Burton +14 more
TL;DR: A large number (33) of human Fab fragments reacting with HIV-1 surface glycoprotein gp120 have been generated by selection from a combinatorial IgG1 kappa library displayed on the surface of phage.