L
Laura E. Maida
Researcher at Torrey Pines Institute for Molecular Studies
Publications - 5
Citations - 115
Laura E. Maida is an academic researcher from Torrey Pines Institute for Molecular Studies. The author has contributed to research in topics: Binding site & Allosteric regulation. The author has an hindex of 5, co-authored 5 publications receiving 103 citations.
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Journal ArticleDOI
Discovery of Novel Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) Using Glycosylated and Non-Glycosylated Substrates
Dmitriy Minond,Mare Cudic,Nina Bionda,Marc A. Giulianotti,Laura E. Maida,Richard A. Houghten,Gregg B. Fields +6 more
TL;DR: Modulation of proteolysis via glycosylation may be used for identifying novel, potentially exosite binding compounds in ADAM proteases and represent research tools to investigate the role of ADAM17 in the progression of various diseases.
Journal ArticleDOI
Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies.
Jinhua Wu,Yaohong Zhang,Yaohong Zhang,Laura E. Maida,Radleigh G. Santos,Gregory S. Welmaker,Travis LaVoi,Adel Nefzi,Yongping Yu,Yongping Yu,Richard A. Houghten,Lawrence Toll,Marc A. Giulianotti +12 more
TL;DR: The use of mixture based combinatorial libraries for the rapid discovery of a series of α4β2 nAChR selective compounds suitable for future optimization toward the goal of developing clinically relevant smoking cessation medications is reported.
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Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities.
Miao Hu,Marc A. Giulianotti,Jay P. McLaughlin,Jiaan Shao,Ginamarie Debevec,Laura E. Maida,Phaedra Geer,Margaret E. Cazares,Jaime A. Misler,Ling Li,Colette T. Dooley,Michelle L. Ganno,Shainnel O. Eans,Elisa Mizrachi,Radleigh G. Santos,Austin B. Yongye,Richard A. Houghten,Yongping Yu,Yongping Yu +18 more
TL;DR: A novel class of peptides incorporating chiral α-hydroxy-β-phenylalanine (AHPBA), and/or Dmt(1)-Tic(2) at different positions was synthesized, adding to the potentially therapeutically relevant collection of previously reported EM analogues.
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A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.
Marc A. Giulianotti,Ginamarie Debevec,Radleigh G. Santos,Laura E. Maida,Wenteng Chen,Wenteng Chen,Lili Ou,Lili Ou,Yongping Yu,Yongping Yu,Colette T. Dooley,Richard A. Houghten +11 more
TL;DR: A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.
Journal ArticleDOI
Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library.
Yangmei Li,Colette T. Dooley,Jaime A. Misler,Ginamarie Debevec,Marc A. Giulianotti,Margaret E. Cazares,Laura E. Maida,Richard A. Houghten +7 more
TL;DR: Two cyclic peptides exhibited high binding affinities to opioid receptor and were selective for the mu-opioid receptor in a binding assay for mu opioid receptor.