Laura L. Bronsart

TL;DR: It is observed that only microvesicles (MVs) can functionally transfer loaded reporter molecules to recipient cells, largely by delivering plasmid DNA, and that exosomes and MVs are structurally and functionally distinct.

TL;DR: A broadly applicable, longitudinal strategy for probing interactions among cells in living subjects that relies on the generation of bioluminescent light when two distinct cell populations come into close proximity and will facilitate probing of numerous types of cell–cell interactions.

TL;DR: This study establishes the importance of macrophages in driving tumor cell recruitment to sites of local radiation therapy and suggests that this mechanism contributes to local recurrence in women with TNBC that are also immunosuppressed.

TL;DR: In vivo imaging with coelenterazine revealed that beta cells of the pancreas have increased levels of superoxide anion, which acted as a measure of beta-cell function and mass and could predict the susceptibility of mice to diabetes mellitus.

TL;DR: Coelenterazine offers a high-throughput method for assessing immune cell activation in culture and provides a means for the in vivo detection and localization of ROS during IBD disease progression.