M
Manish J. Butte
Researcher at University of California, Los Angeles
Publications - 170
Citations - 15868
Manish J. Butte is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Medicine & T cell. The author has an hindex of 38, co-authored 135 publications receiving 12961 citations. Previous affiliations of Manish J. Butte include Brown University & University of California, San Francisco.
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Journal ArticleDOI
PD-1 and its ligands in tolerance and immunity
TL;DR: Current understanding of the immunoregulatory functions of PD-1 and its ligands and their therapeutic potential are discussed and an inhibitory bidirectional interaction between PD-L1 and B7-1 is discovered, revealing new ways the B7:CD28 family regulates T cell activation and tolerance.
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Patterned Paper as a Platform for Inexpensive, Low‐Volume, Portable Bioassays
TL;DR: This communication describes a simple method for patterning paper to create well-defined, millimeter-sized channels, comprising hydrophilic paper bounded by hydrophobic polymer, that will become the basis for low-cost, portable, and technically simple multiplexed bioassays.
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Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
TL;DR: These findings point to a substantial bidirectional inhibitory interaction between B7-1 and PD-L1 and add an additional dimension to immunoregulatory functions of the B7:CD28 family.
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Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy
Ning Sun,Masayuki Yazawa,Jianwei Liu,Leng Han,Veronica Sanchez-Freire,Oscar J. Abilez,Enrique G. Navarrete,Shijun Hu,Li Wang,Andrew S. Lee,Aleksandra Pavlovic,Shin Lin,Rui Chen,Roger J. Hajjar,Michael Snyder,Ricardo E. Dolmetsch,Manish J. Butte,Euan A. Ashley,Michael T. Longaker,Robert C. Robbins,Joseph C. Wu +20 more
TL;DR: Human induced pluripotent stem cells generated from patients with familial dilated cardiomyopathy model cardiovascular disease could provide an important platform to investigate the specific disease mechanisms of DCM as well as other inherited cardiovascular disorders and for screening new drugs for cardiovascular disease.
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TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.
Norimoto Kobayashi,Piia Karisola,Victor Pena-Cruz,David M. Dorfman,Masahisa Jinushi,Sarah E. Umetsu,Manish J. Butte,Haruo Nagumo,Irene Chernova,Baogong Zhu,Arlene H. Sharpe,Susumu Ito,Glenn Dranoff,Gerardo G. Kaplan,José M. Casasnovas,Dale T. Umetsu,Rosemarie H. DeKruyff,Gordon J. Freeman +17 more
TL;DR: The results show that TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity.