L
Lauren A. Zenewicz
Researcher at University of Oklahoma Health Sciences Center
Publications - 52
Citations - 6943
Lauren A. Zenewicz is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Immune system & Interleukin 22. The author has an hindex of 27, co-authored 47 publications receiving 6251 citations. Previous affiliations of Lauren A. Zenewicz include Yale University & University of Pennsylvania.
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Journal ArticleDOI
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
Lauren A. Zenewicz,George D. Yancopoulos,David M. Valenzuela,Andrew J. Murphy,Sean Stevens,Richard A. Flavell +5 more
TL;DR: It is shown that IL-22 protected mice from IBD, and Interestingly, not only was this protection mediated by CD4+ T cells, but IL- 22-expressing natural killer (NK) cells also conferred protection.
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Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor.
TL;DR: The level of accumulation of berberine in the cells was increased strongly in the presence of 5'-MHC, indicating that this plant compound effectively disabled the bacterial resistance mechanism against the berberines antimicrobial.
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Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.
Lauren A. Zenewicz,George D. Yancopoulos,David M. Valenzuela,Andrew J. Murphy,Margaret Karow,Richard A. Flavell +5 more
TL;DR: Evidence is provided that during inflammation, IL-22 played a protective role in preventing tissue injury and interleukin-17, which is coexpressed withIL-22 and can induce similar cellular responses, had no observable role in liver inflammation.
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IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Samuel Huber,Nicola Gagliani,Lauren A. Zenewicz,Francis J. Huber,Lidia Bosurgi,Bo Hu,Matija Hedl,Wei Zhang,William T. O'Connor,Andrew J. Murphy,David M. Valenzuela,George D. Yancopoulos,Carmen J. Booth,Judy H. Cho,Wenjun Ouyang,Clara Abraham,Richard A. Flavell,Richard A. Flavell +17 more
TL;DR: It is described that IL-22BP has a crucial role in controlling tumorigenesis and epithelial cell proliferation in the colon in steady-state conditions and the IL- 22–IL-22 BP axis critically regulates intestinal tissue repair and tumorsigenesis in the Colon.
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Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity
TL;DR: In this paper, the authors highlighted the importance of regulatory cytokines in controlling the differentiation and function of lymphocytes under steady-state and inflammatory conditions, as well as minimizing tissue damage.