Bo Hu

TL;DR: It is proposed that understanding this microbial influence will be crucial for targeted therapy in modern cancer treatment and the recently suggested role of commensal microorganisms in inflammation-induced cancer is discussed.

TL;DR: It is described that IL-22BP has a crucial role in controlling tumorigenesis and epithelial cell proliferation in the colon in steady-state conditions and the IL- 22–IL-22 BP axis critically regulates intestinal tissue repair and tumorsigenesis in the Colon.

TL;DR: In this paper, the authors provide evidence that local microbiota provoke inflammation associated with lung adenocarcinoma by activating lung resident γδ T cells, and link local microbiota-immune crosstalk to lung tumor development and define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.

TL;DR: This work suggests a model in which the NLRC4 inflammasome is central to colonic inflammation-induced tumor formation through regulation of epithelial cell response to injury and shows that caspase-1–deficient mice have enhanced tumor formation.

TL;DR: The results mechanistically link the altered microbiota with the pathogenesis of inflammation-induced CRC and suggest that in some conditions, microbiota components may transfer CRC susceptibility between individuals.